DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp98A and kif13b

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_031758942.1	Gene:	kif13b / 100492799	XenbaseID:	XB-GENE-956968	Length:	1943	Species:	Xenopus tropicalis

Alignment Length:	907	Identity:	316/907 - (34%)
Similarity:	465/907 - (51%)	Gaps:	135/907 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFD-A 65
            |::|||||:||.|.||:|:..:.::::||.:..|........:...|.....|.:|:.:||.| :
Frog     4 STVKVAVRIRPMNRREVDLQTKCVVDVENNQIVLYPSNASLSKGDARSQPKVFAYDHCFWSMDES 68

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFAR 130
            ....||.|:.|:..||.:::..|:||||||:||||||||||::|||||.:.||||||:|..||.|
Frog    69 VKEKFAGQDVVFQCLGENILQNAFEGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSTLFER 133

  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195
            .:..:.....::...|::|||||:|:|||..:.:...|:||||:.|||||:.||:.||:.:.:|:
Frog   134 TQKAENEELSFKVEVSFMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSKLAVTSYKDIE 198

  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPS----ETVSKIHLVDLAGSERAN 256
            ..::.||..||.|:||||:.||||||:|.|.....:.  |:.|    |.|||:.||||||||||.
Frog   199 SLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLV--DVKSGTSGEKVSKLSLVDLAGSERAT 261

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            .|||.|:|||||::|||||.|||.||||||:| |.|.|.:.               ::|||||:|
Frog   262 KTGAAGERLKEGSNINKSLTTLGLVISALADQ-GAGKNKNK---------------FVPYRDSVL 310

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||||||||||||.|:|.:|||..||.|||||||||:|||||:|...||||.|.::|||||||:
Frog   311 TWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKNIVNHAVVNEDPNARIIRELREEV 375

  Fly   387 NKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQ----KSLGLRKSG 447
            .||:..|........|.||  ..||:.|...:.:|..|.||.::.:.|.||:    :|||:....
Frog   376 EKLRVQLTQAESMKAPELK--ERLQESEKLIQEMTVTWEEKLRMTEDIAQERQKQLESLGISLQS 438

  Fly   448 VGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLK- 510
            .|:.:......|:.::.| ....:.:|.||: .|.|||.|   :|||:|.|.||..:||.|.:.
Frog   439 SGIKVGDNKSFLVNLNADPALNELLVYYLKD-HTLIGSHD---SQDIQLCGLGILPEHCIIDISP 499

  Fly   511 GGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSR 575
            .|.|.|.|....:.:||...:.:..|:..||.||.|..:.||.:.|      :|..::.:.:...
Frog   500 EGQVILTPMKNTRTYVNGSAVTKATQLQHGDRILWGNNHFFRISLP------KKKKAKQEDEEQD 558

  Fly   576 LSLITSSKENLLTCSIYSDEDGASP----YKRPERQYYPQRPMSRDDPELQDENRKILDTIENAL 636
            .||..||....|.....|..:|:|.    |:..:.:.. .:.:..:||     .:.||.::|
Frog   559 SSLRNSSSFEQLDLDGDSSSEGSSEVNFNYEYAQMEIM-MKALGNNDP-----MQSILQSLE--- 614

  Fly   637 KQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQID 701
                    |.|::.|   |...|....:.:.|:|.|:.....|::.....|...:...|.:.:|
Frog   615 --------QQHEEEK---RSALERQRLMYEHELDQLRRRLSPEKQHYRSMDRFSFGSPNAQQRI- 667

  Fly   702 IVCRQ-ISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDL 765
               || ....:..|:...|...|.:||....:|:
Frog   668 ---RQWTEEREAMLNQSLRKLREQIAKANLHVQE------------------------------- 698

  Fly   766 FAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQ--------LERLRL 822
              |.||.:.:.:..|  .|:..||....  |||:..:.|.:.|..::::.:        ||:|
Frog   699 --ANFIAEEMDKRTE--YKVTLQIPASS--LNANKKRGAVLSEPAIQVRRKGKGKQIWSLEKL-- 755

  Fly   823 ERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLV 884
                 |.....:|...|..|            ..:|.|.:|:| .:...|.|:....|.||:
Frog   756 -----ENRLVDIRDLYQEWK------------ECDEDDPMSRS-YFRRADPFYDEHENHSLI 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	186/373 (50%)
		KISc	3..371	CDD:214526	185/372 (50%)
		Kinesin_assoc	370..478	CDD:292801	37/112 (33%)
		FHA	456..555	CDD:238017	34/100 (34%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
kif13b	XP_031758942.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	186/373 (50%)
		Kinesin_assoc	357..469	CDD:406567	36/113 (32%)
		FHA	449..544	CDD:238017	34/98 (35%)
		KIF1B	755..801	CDD:403579	14/65 (22%)
		DUF3585	<1097..1141	CDD:419985
		DUF3694	<1185..1277	CDD:403614
		CAP_GLY	1810..1873	CDD:396049
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920