DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and kif16b

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_012819297.1	Gene:	kif16b / 100489716	XenbaseID:	XB-GENE-948787	Length:	1837	Species:	Xenopus tropicalis

Alignment Length:	1353	Identity:	486/1353 - (35%)
Similarity:	699/1353 - (51%)	Gaps:	268/1353 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQS--IRDAGRDNHHDFTFDYSYWSF 63
            |:|:||||||||.|.||.|::|:.|:|||.|||.:...::..  ..|.||:....||:|:||:|.
Frog     1 MASVKVAVRVRPMNRREKDLEAKFIIEMEGKKTTITNIKMPDGISGDLGRERTKTFTYDFSYFSV 65

  Fly    64 DAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELF 128
            |:::..:|:||:|:.|||.||:..|:||||||:||||||||||::||||.|.:.||||||||.||
Frog    66 DSKNIDYASQERVFKDLGTDVLQSAFEGYNACIFAYGQTGSGKSYTMMGNPGDSGLIPRICEGLF 130

  Fly   129 ARM----RVGQESGTGYRTHASYLEIYNERVKDLLAAQST-GHGLRVREHRSLGPYVENLSQHAV 188
            :|:    |.|..|   :||..||||||||||:|||..:|: ...||||||...|||||:||:|.|
Frog   131 SRIAETTRWGDAS---FRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLV 192

  Fly   189 SDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSE 253
            .::.:::|.:..||..||||:|.|||.||||||||||.|.||.|..:||.|||||||||||||||
Frog   193 QNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTINFTQAKFDAEMPCETVSKIHLVDLAGSE 257

  Fly   254 RANATGATGQRLKEGAHINKSLVTLGSVISALAE--QTGGGHNSSSSALATTPNGASKRVLYIPY 316
            ||:||||||.|||||.:|||||||||:||||||:  |....|.            |.|:.:::||
Frog   258 RADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANHL------------AKKKQVFVPY 310

  Fly   317 RDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRE 381
            |||:|||||||||||||||||||.:||||.||.||||||||||||||||||||:|||.|||||||
Frog   311 RDSVLTWLLKDSLGGNSKTIMIATISPADINYGETLSTLRYANRAKNIINKPTINEDANVKLIRE 375

  Fly   382 LREEINKLKSMLA-GDIHSLQPS---LKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLG 442
            ||.||.:||::|| |:..:|..|   |.:...||:.||:.:.||:|||.||...|:||:|| :|.
Frog   376 LRAEIARLKALLAQGNQIALLDSPTALSMEEKLQQNEARVEELTKEWTNKWNETQNILKEQ-TLA 439

  Fly   443 LRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCS 506
            |||.|:|||||||:||||||.:| ::||:.||.||||.|.:|.|||...|||.|.|..:.::||.
Frog   440 LRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGRTYVGREDAAADQDIVLHGLDLESEHCI 504

  Fly   507 IFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQL 571
            .....|.|||.|...:||.||...|.|..|::||.:|||||||:||||:|.||||||:......|
Frog   505 FENLSGTVTLIPLNGSQCSVNGVQIQESTQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLL 569

  Fly   572 DMSRLSLITSSK--ENLLTCSIYS----------DEDGASPYKR------PERQYYPQRPMSRDD 618
            ....||:...||  |||....:|:          :|......||      .|:|.|.:..:.:..
Frog   570 SSFSLSMTDLSKSCENLSAVMLYNPGLEFERQQREELEKLENKRKLIKEMEEKQKYEKAELEKMQ 634

  Fly   619 PELQDE------------------NRKILDTIENALKQLNVERVQMHD-------QYKTKVRKLT 658
            .|::.:                  .|:.|| ||:.|:.|..|:::..:       :.:.:.:|..
Frog   635 QEVESQRKETEIVQLHIRKQEESLKRRSLD-IESRLQDLLAEKIKFEEERLREQQEIELQKKKQQ 698

  Fly   659 EELIRLEQEEMDGLQLLNCREQ----ELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKR 719
            ||.....|||:..||.|:..|:    |:....:.|..||:::.::::       |.:.:|:.::|
Frog   699 EESFIKVQEELQRLQELHNTEKGEKMEIFRELEKLKKEKDDQYLKLE-------AEKKRLEEQER 756

  Fly   720 DFSEYV---AKELQELQ---------DCGKL-DEMGM-----------------------KIEEG 748
            :..:.|   .::|:|.|         |..:| :|:|:                       ::|:.
Frog   757 EQLKLVFRLEEQLREKQEMILLFERGDVSRLEEEIGVLEDVREDLLRAKEARSEGEGDPEEVEKA 821

  Fly   749 TPLNDELLLQVSDSLDLFAAQF----------IK---DTVRR------NNEEIRKLDE------- 787
            |....|......|.|.:.....          ||   ||:.|      .|.|:.|.::
Frog   822 TNKYTEFKRMQVDKLSVLEGDLHRQTDCLEKEIKADHDTLSRLCLSNVENTELHKTEDESSLVTP 886

  Fly   788 QIAE--------------KER----------------------ILNASTTKIAKVDETMLEIQAQ 816
            ||||              |||                      |||:.   :..:|:|:.:|:.:
Frog   887 QIAEELEMIKQTENKIHCKERQLKYINQTHLPALFDEKQRASEILNSG---LLGLDKTLYQIEKE 948

  Fly   817 LERLRLERAESEAESQAMR-----------AKKQNMKLQLGNKSMSTSTSTNEADDVSKS----- 865
            :|....:.|:..|.|..::           ..:|..|::...|.:..|....:.:.:.::
Frog   949 IEEKADQLAQFRASSDQLQQLQETFEFTTNIARQEEKVRRKEKEILESREKQQREALEQAVAKLE 1013

  Fly   866 ------DTYETCDT-FHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEET 923
                  ..:.|.|. ....:..|:.:::.....|.|:.|     :||.:|.:..::.|:...::.
Frog  1014 RRHSALQRHSTIDVEIEEQKCKLAALNNSKEQAGLQATL-----EAEQKALEQDRERLAHEIQQL 1073

  Fly   924 SRTC-TAGPSSGSGSGSV----GIGGSGSAPSCTPSSQAIMSDSGV--CLDSRNQAILQNGHL-- 979
            .:.. .|.|.|.|.||||    .:..|.::|..:.|....::|..:  .::...|..|||.::
Frog  1074 KQKIHVADPLSKSLSGSVEEKPSLVNSPASPVKSQSHLLTLNDDRIHAYIEEEVQRRLQNINMSC 1138

  Fly   980 NNYKQAVRTSDEDTGSCSSCELG-------RHSDVARP--YC-----------PLHSLRR----- 1019
            :|......||..|.|..|...|.       ::.:|..|  :|           .||.|.|
Frog  1139 DNLNGLSLTSSADFGMSSDAFLNGATQRKLKYENVQHPEKFCNVPMPGTKTTSVLHDLERPECRH 1203

  Fly  1020 ------------KI--AAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQDLE 1070
                        ||  .:|:....|..|..:..:.:.|:...|.|.:   .::.|....::...:
Frog  1204 LAPVTDALSDPSKIFSGSQEKYFSKGNEKGIYGSSISEYFDVLADTK---CELSQLFSNNISSSK 1265

  Fly  1071 AHAQC--CADERSGMERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCP 1121
            ...:|  ||..:...:.|.:|:.|.:.......|. .:.||....||:.|..|
Frog  1266 GSHECAPCASFQLPQQSQVKLSESALCHQDFLKTE-SDWTSMHQMPSLVRVTP 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	231/377 (61%)
		KISc	3..371	CDD:214526	231/376 (61%)
		Kinesin_assoc	370..478	CDD:292801	63/112 (56%)
		FHA	456..555	CDD:238017	51/99 (52%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
kif16b	XP_012819297.1	KISc_KIF1A_KIF1B	2..365	CDD:276816	231/377 (61%)
		Kinesin_assoc	364..476	CDD:374417	63/112 (56%)
		FHA	478..543	CDD:366133	27/64 (42%)
		SbcC	<600..>1078	CDD:223496	84/493 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I652
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	1	1.000	-	-		FOG0008326
OrthoInspector	1	1.000	-	-		oto102628
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5551
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110