DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and kif13a

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_009291008.1	Gene:	kif13a / 100331282	ZFINID:	ZDB-GENE-090901-1	Length:	1937	Species:	Danio rerio

Alignment Length:	1454	Identity:	413/1454 - (28%)
Similarity:	626/1454 - (43%)	Gaps:	398/1454 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66
            :.:||||||||.|.|||:::.:.::|||:.:| :|.|...:.:...|.....|.||:.:||.|..
Zfish     4 TKVKVAVRVRPMNRREIELNTKCVVEMEDNQT-VLHPPPSNAKGESRKQPKVFAFDHCFWSMDES 67

  Fly    67 D-PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFAR 130
            : |.:|.||.|:..||..::..|::|||||:||||||||||:|:|||:.:.||||||:|..||.|
Zfish    68 NIPKYAGQEVVFKCLGEGILQNAFQGYNACIFAYGQTGSGKSFSMMGSGDQPGLIPRLCCSLFER 132

  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195
            :...|.....::...||:|||||:|:|||..:.:...|:||||:.|||||:.|||.||:.|::|:
Zfish   133 VSTQQSDSNSFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFEDIE 197

  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPS----ETVSKIHLVDLAGSERAN 256
            ..::.||..||.|:||||:.||||||:|::...|.::  |:.|    |.||||.|||||||||.:
Zfish   198 SLMSEGNKSRTVAATNMNEESSRSHAVFSVILTQTLY--DLQSGNSGEKVSKISLVDLAGSERVS 260

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            .|||.|:|||||::|||||.|||.||||||:|:.|                ..|..::|||||:|
Zfish   261 KTGAAGERLKEGSNINKSLTTLGCVISALADQSAG----------------KSRNKFVPYRDSVL 309

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||||:|||||||.|||.:|||..||.|||||||||:|||.|:|...||||.|.::|||||||:
Zfish   310 TWLLKDNLGGNSKTAMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELREEV 374

  Fly   387 NKLKSMLAGDIHSLQPSLKVLADLQKK-EAQEKVLTE---EWTEKWKVAQSILQEQ----KSLGL 443
            .||:..|     |...|||. .:||:| :..||::.|   .|.||.:..:.|.||:    :|:|:
Zfish   375 EKLREQL-----SQAESLKA-PELQEKLQESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESMGI 433

  Fly   444 RKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSI 507
            .....|:.:..:...|:.::.| ....:.:|.||: .||:|   ||..|||:|.|.||:::||.:
Zfish   434 SLESSGIKVGEDKSFLVNLNADPALNELLVYYLKD-HTRVG---ADTTQDIQLFGIGIQSEHCVL 494

  Fly   508 FLKG-GVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRS-- 569
            .:.. |.|||.|...|:..||..::.....:..||.||.|..:.||.|.|..  |.||||.|.
Zfish   495 EVTADGDVTLTPAHNARTCVNGMMVYSKVHVWHGDRILWGNNHFFRVNLPNR--KRRKDLDRGSP 557

  Fly   570 -----QLDMSRLSLITSSKE--------NLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPEL 621
                 :.|:...|..:|.::        .::..::.:::...:..:..|:||..::.::.::..|
Zfish   558 RESFIEADVETASEASSEQDYSYEFAQMEVMMKALGNNDPMQNAVQALEKQYVEEKRLALEEQRL 622

  Fly   622 QDENRKILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGL---QLLNCREQELI 683
            ..|..     :::..:||..||...|.:....... |...:||..||.|.|   .|...|||  :
Zfish   623 MYERE-----LQSLRQQLTPERNTQHQRLSYNTHN-THSRLRLWTEERDELFRQSLSRLREQ--V 679

  Fly   684 ARKDMLLWEKN--NEKVQ--------IDIVCRQISAFQ-------------------TQ------ 713
            .|.:.|:.|.|  :|::|        :.|....:||.:                   ||
Zfish   680 VRANALVREANFLSEEMQKHTDYQATLQIPAANLSANRKRGAIVSEPAIQVRRKGKGTQVWTIEK 744

  Fly   714 LDSK-------KRDFSE-----------------YVAKELQEL-------QDC------------ 735
            |::|       .||:.|                 |.|:|...|       .:|
Zfish   745 LENKLVDMRDHYRDWREGAQELVNRLHNKAGDPFYEAQENHNLIGVANVFLECLFHDVRLQYAVP 809

  Fly   736 ---------GKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAE 791
                     |:|....:::....|   |.|....||.:..:.....|.: .||.||..:..::..
Zfish   810 IISQQGEVAGRLHVELLRVSGAVP---ERLCGGDDSSENSSESSGYDFM-DNNGEIVHMARKLTC 870

  Fly   792 KERILNAS-------------------------------------------TTK-------IAKV 806
            :.||..||                                           |.:       :.:|
Zfish   871 RVRIKEASGLPLHLSNFVFCQYSFWDQSEPTVAPPLVSPDTPTARSHDQEFTVRFNHCRDFVVQV 935

  Fly   807 DETMLEIQAQLERLRLE--------RAESEAESQAMRAKKQNMKLQLGNKSMS-----TSTSTNE 858
            .|..||..:. ..|.:|        ...|..|:..::|||:.::.:....|.|     :....||
Zfish   936 TEEFLEFISD-GALAIEVWGHRYTGNGRSVWETHTLQAKKRTLRDRWSEVSRSIELWVSIQELNE 999

  Fly   859 ADDVSKSDTYETCDT-----FHTAQSN---LSLVSSPTITEGQ---------------------- 893
            ..:.|..:.:.|.|:     |...|.:   |.:...|....|.
Zfish  1000 QGEYSSVELHNTKDSSTGGVFQLRQGHSRRLQVCVQPVQHSGTLPLLVEAVLSVSIGCVTARSTK 1064

  Fly   894 -QSPLS-----------------NCSCDAEDEAEDTRKDDLS----------------------- 917
             |.||.                 ||..|...:|...|::.|.
Zfish  1065 LQRPLDSYQEEDGDMDSYQEEDLNCVRDRWSDALIKRREYLEEQIKIILNKPEKSEEDIEREARL 1129

  Fly   918 -----GSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNG 977
                 |.:||.:......|:||.         .|:.....|.:........:.||.....:..|.
Zfish  1130 VEQWVGLTEERNAVLVPAPASGI---------PGAPAHWVPPAGMEAHIPVLFLDLNADNLTVND 1185

  Fly   978 HLNN-------------------YKQAVRTSDEDTGSCSSCELGRHSDVARPYCPLHSLRRKIAA 1023
            ||..                   |...:|.||::..:..|.:...|..:       |..|...|.
Zfish  1186 HLTGPHAAGVNSILPKEHGSSFFYLPIIRHSDDEVSAVCSWDSSIHDSI-------HLNRITAAN 1243

  Fly  1024 QKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQM----EQEMLQSVQ---DLEAHAQCCADERS 1081
            ::..::......|:      |.|.::.|.|:.|.:    :|...||::   .|:.....|
Zfish  1244 ERVYLIVKAAVQLS------HPACVELLLRKRIAVNIYNKQSFTQSLKRRMSLKNMLYSC----- 1297

  Fly  1082 GMERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVMRGAGKQ 1146
            |:  .||:.|:|       |.:.||              |..||        |:.....||..::
Zfish  1298 GV--TYEIVSNI-------PKASEE--------------PEERE--------TLALMAARGENEE 1331

  Fly  1147 THYEYEVRIALPDGKLNILRRYSR 1170
            |.          ||: ..:.:|:|
Zfish  1332 TR----------DGE-TYIEKYTR 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	191/373 (51%)
		KISc	3..371	CDD:214526	191/372 (51%)
		Kinesin_assoc	370..478	CDD:292801	39/116 (34%)
		FHA	456..555	CDD:238017	34/100 (34%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	8/40 (20%)
kif13a	XP_009291008.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	191/372 (51%)
		KISc	6..359	CDD:214526	191/371 (51%)
		Kinesin_assoc	356..468	CDD:292801	38/117 (32%)
		FHA	448..543	CDD:238017	34/98 (35%)
		KIF1B	745..790	CDD:289208	9/44 (20%)
		DUF3585	<1098..1142	CDD:304905	5/43 (12%)
		DUF3694	<1211..1279	CDD:289256	14/80 (18%)
		CAP_GLY	1859..1921	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920