DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and kif13bb

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_009299747.1	Gene:	kif13bb / 100317281	ZFINID:	ZDB-GENE-090908-5	Length:	2095	Species:	Danio rerio

Alignment Length:	1337	Identity:	401/1337 - (29%)
Similarity:	607/1337 - (45%)	Gaps:	305/1337 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSI-RDAGRDNHHDFTFDYSYWSFD- 64
            |::||||||||.|.||.|:..:.::|||..:| :|.|...:: :...|.....|.:||.:||.|
Zfish    10 SNVKVAVRVRPMNRRERDLKTKCVVEMEGNQT-ILYPASGNLGKGDSRAKPKCFAYDYCFWSMDE 73

  Fly    65 AEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFA 129
            ||...||.|:.|:..||..::|.|::|||||:||||||||||::||||:...||||||:|..||.
Zfish    74 AETGKFAGQDVVFQCLGESLLDSAFQGYNACIFAYGQTGSGKSYTMMGSSEQPGLIPRLCSSLFE 138

  Fly   130 RMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEI 194
            |..:.|..|..:....||:|||||:|:|||..:.:...|:||||..|||||:.||:.|||.:.:|
Zfish   139 RSVLEQREGESFTVEVSYMEIYNEKVRDLLDPKGSRQALKVREHNVLGPYVDGLSRLAVSSYKDI 203

  Fly   195 QECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPS----ETVSKIHLVDLAGSERA 255
            :..::.||..||.|:||||:.||||||:|.|.....  :.||.:    |.|||:.||||||||||
Zfish   204 ESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHT--LRDMKTGTSGEKVSKLSLVDLAGSERA 266

  Fly   256 NATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSI 320
            :.|||.|:|||||::||:||.|||.|||||||| |.|.|.|.               ::|||||:
Zfish   267 DKTGAAGERLKEGSNINRSLTTLGLVISALAEQ-GAGKNKSK---------------FVPYRDSV 315

  Fly   321 LTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREE 385
            |||||||||||||:|.|:||:|||..||.|||||||||:|||:|||...||||.|.::|||||||
Zfish   316 LTWLLKDSLGGNSRTAMVAAVSPAADNYEETLSTLRYADRAKSIINHAVVNEDPNARIIRELREE 380

  Fly   386 INKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQ----KSLG--LR 444
            :.||:|.|:.......|.||...:..:|..||  :|..|.||.:..:.|.||:    :|||  |:
Zfish   381 VEKLRSQLSEAESMKAPELKERLEESEKLIQE--MTVSWEEKLRKTEEIAQERQKQLESLGISLQ 443

  Fly   445 KSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIF 508
            .||:.|:  .|...|:.::.| ....:.:|.||| .||:||.|   :|||:|.|..|:.:||.|.
Zfish   444 SSGIRVI--DEKCFLVNLNADPALNELLVYYLKE-HTRVGSAD---SQDIQLCGLAIQPEHCIID 502

  Fly   509 LKGGV-VTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFN-------NPAEAAKLRKD 565
            :|... |||.|...|:..||..::....|:..||.||.|..:.||.:       ...:...::..
Zfish   503 IKPETGVTLTPKRNARTCVNGAVVSSAIQLHHGDRILWGNNHFFRISVSNVYRVEDEDGCVMKAG 567

  Fly   566 LSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILD 630
            |....||:.||||.:|              |.:..::..:.:.. .:.:..:||     .:.:|.
Zfish   568 LRSDHLDVDRLSLASS--------------DTSFSFESAQTEVM-MKALGNNDP-----MQSVLH 612

  Fly   631 TIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCR-EQELIARKDMLLWEKN 694
            ::|           :.|::.|...  |..:.:..|||    ||.|..| ..||..:.......::
Zfish   613 SLE-----------RRHEEEKRSA--LERQRLMYEQE----LQQLRKRLSSELQTQSSHPQHHRS 660

  Fly   695 NEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQV 759
            :|         |::|......|:.|.:::  .:|:...:...||.|..:|.        .||:|
Zfish   661 SE---------QLNASALSSQSRLRQWTD--DREVLMSRSLRKLREQIVKA--------NLLVQ- 705

  Fly   760 SDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQ---LERLR 821
                   .|.||.:.:.:..|  .|:..||....  |||:..:...:.|..:|::.:   .:...
Zfish   706 -------EAGFIAEDLNKKTE--YKVTLQIPAAN--LNANRKRDTVLSEPAIEVRRKGKGKQIWA 759

  Fly   822 LERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLV-- 884
            ||:.|:....  ||...|..|             ..:.||.:....::..|.|...|.|.||:
Zfish   760 LEKIENRLVD--MRDLYQEWK-------------DYDEDDPAMRSYFKRADPFFDEQENHSLIGV 809

  Fly   885 ----------------SSPTITE-GQQS-----PLSNCSCDAEDEAEDTRKDDLSGSSEETSR-- 925
                            :.|.|.: |:.|     .:...|...|:...||...:.|..||...|
Zfish   810 ANVFLSCLLYEVKLQYAVPIINQKGEVSGRLHVEVERLSGGLEESETDTGDSENSPESEMQERKF 874

  Fly   926 TCTAGPSSGSG------------------------SGSVGIGGSGSA--------PSC------- 951
            ||.......:|                        :..||:..:.|.        .:|
Zfish   875 TCMIKVLQATGLPQHLSNFVFCQYHFWDQPEPVFIAPEVGLSAASSREPQSLVVFDNCKTLEVAV 939

  Fly   952 TPSSQAIMSDSGVCLD---------SRNQAILQNGHLNNYKQAVR----------------TSDE 991
            |...|..:.:..|.::         .||.|:...|.:....:::|                ....
Zfish   940 TEDFQEFLMEGAVAVEVYGHKQENPRRNLALWDLGVIQAKTRSLRERWSEVTRRLELWVQVLEIN 1004

  Fly   992 DTGSCSSCELGRHSDVA-------------RPYCPLHSLR-----------------RKIAAQKA 1026
            |||.....|:....||.             |.:..:.|::                 ..:..|:|
Zfish  1005 DTGVFVPVEVQPAKDVCTGGIFQLKQGQSRRVHVEVRSVQDSGTLPLIAESVLSISMGNVEVQQA 1069

  Fly  1027 LIMKNLETD-LNKAQLDEH-IADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYEL 1089
            ...|:.:|. :....:|.: ..||:.|:.:::   ..:.|..:.|:...|....:::..|...|.
Zfish  1070 RTAKSTDTQRVGDKDMDSYQEVDLERLRAKWL---TALTQRQEYLDQRLQKLVSKQNKSEEDVES 1131

  Fly  1090 ASSIM---------RSSVMSPTS----------------MEESTSQIY------------SPSMT 1117
            .|.::         |:||:.|::                ||.....|:            ||.:.
Zfish  1132 ESQLLECRLTLTEERNSVLVPSAGSGIPGAPAEWVPVPGMETHIPVIFLDLNADDLHDHLSPPLA 1196

  Fly  1118 RSCPSMREFPEGEHFITIPSFVMRGAGKQTHYEYEVR 1154
            ....::.:..:.|.||.:.  :::      |||.||:
Zfish  1197 GGLDAVLKREDKEDFIDLQ--IVK------HYENEVK 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	197/374 (53%)
		KISc	3..371	CDD:214526	196/373 (53%)
		Kinesin_assoc	370..478	CDD:292801	42/114 (37%)
		FHA	456..555	CDD:238017	36/107 (34%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	7/24 (29%)
kif13bb	XP_009299747.1	KISc_KIF1A_KIF1B	10..366	CDD:276816	197/374 (53%)
		KISc	11..366	CDD:214526	196/373 (53%)
		Kinesin_assoc	363..475	CDD:292801	41/115 (36%)
		FHA	453..550	CDD:238017	36/100 (36%)
		KIF1B	764..809	CDD:289208	13/59 (22%)
		DUF3694	<1224..1282	CDD:289256	1/2 (50%)
		CAP_GLY	1983..2046	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920