DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and kif14l

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_002938797.1	Gene:	kif14l / 100145032	XenbaseID:	XB-GENE-5889659	Length:	1547	Species:	Xenopus tropicalis

Alignment Length:	1195	Identity:	338/1195 - (28%)
Similarity:	558/1195 - (46%)	Gaps:	258/1195 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66
            :::.|||||||.|.||:....:.:|.:..:..::..|:        .:.|..|.:|:.:||.:..
Frog   289 TAVTVAVRVRPLNERELSSGYKCVMFVLGQTIQIQHPQ--------TNQHLSFQYDFCFWSLEPG 345

  Fly    67 DPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARM 131
            |..:|:||.||:.:...::...::|||.|:||||||||||::||||.....|:|||.|||||..:
Frog   346 DSSYASQEVVYNQIAQPLLQGVFQGYNMCLFAYGQTGSGKSYTMMGFNEEAGIIPRFCEELFQNV 410

  Fly   132 R-VGQESGTGYRTHASYLEIYNERVKDLLAA---QSTGH-GLRVREHRSLGPYVENLSQHAVSDF 191
            . .|||. ..|....||.|||||::.|||.:   |:... .|:||||.:.||||..||.:.::.|
Frog   411 GCTGQEE-VKYNVEMSYFEIYNEKIHDLLTSPKDQALNKVALKVREHPTFGPYVAGLSTYVIASF 474

  Fly   192 DEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA---VFMNDMPSET-VSKIHLVDLAGS 252
            .::|..:..||.||.||:|.||:.|||||::|.::..|.   :...::...| .|:::|||||||
Frog   475 ADVQTWLELGNKQRATAATGMNEKSSRSHSVFILSVSQTMRELLEGEVHDHTRTSRVNLVDLAGS 539

  Fly   253 ERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYR 317
            ||.|:...:|.||||||.|||||:|||.|||||:|.:                 ..|:..:||||
Frog   540 ERCNSAQTSGVRLKEGASINKSLLTLGKVISALSEMS-----------------EVKKRSFIPYR 587

  Fly   318 DSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIREL 382
            ||:|||||::||||||||.|||.:|||..|..|:|||||||::|:||||...||||:...|||||
Frog   588 DSLLTWLLRESLGGNSKTAMIATVSPATVNLEESLSTLRYASQARNIINVARVNEDSTAALIREL 652

  Fly   383 REEINKLKS----MLAGDIHSLQPSLKVLADLQKK-EAQEKVLTE---EWTEKWKVAQSILQEQK 439
            :.||:|||:    :...|..:...||..:..|::: ..|||.|||   .|.||.::|:. .:|::
Frog   653 KAEIDKLKAAQQCVQGVDQETYDASLHEIQSLRERLFIQEKELTETQKSWEEKLELAKQ-QKEEE 716

  Fly   440 SLGLRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQ 503
            :..|:|:||...:|:.:|:|:.::.| ..:.|.||.:|:|:|.:|.:......:|:|.|..|...
Frog   717 AKELQKAGVCFKVDNMLPNLVNLNEDPQLSEVLLYIIKKGQTMVGKQHPGSDHEIQLTGALIAEN 781

  Fly   504 HCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSR 568
            ||.|..|.|.|:|.|.|.|:.::|.:|:..|..:..||.::||..:.||||:|.|...:|:.:..
Frog   782 HCLINNKAGQVSLTPLPDAETFINGNLVRNPIVLHHGDRVILGGNHYFRFNHPTEVDSVRRSVMP 846

  Fly   569 SQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRK----IL 629
                                   :::::|...::..:.:.. :....|.:.|::|...:    ::
Frog   847 -----------------------HTNQEGPRDFEFAKNELI-EAQTQRIENEIEDARLQAQTDMM 887

  Fly   630 DTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLL--NCREQELIARKDML--- 689
            ..::.|.:...:|..|..:.|:.::|:|..||    :||::..:.:  :.:|......:|.|
Frog   888 KELQAAKEMAQMELTQQKNLYENRIRQLEREL----EEELERKRSIKRSLKESRPATGRDHLPPS 948

  Fly   690 -LWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLND 753
             |:   ::.|::.|   :.|.|...|:.:|    |.:..:::::|..||......|..:.|.|..
Frog   949 GLY---SQGVEMGI---KHSKFMQVLELEK----ETLVSQVEKMQQQGKKSISAEKQAQWTALQL 1003

  Fly   754 ELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLE 818
            .:.||.::::                             .:.:|..|. .::.|..:|
Frog  1004 SIALQEANTI-----------------------------SKSMNKHTV-FSRYDLPVL------- 1031

  Fly   819 RLRLERAESEAESQAMRAKKQNMKLQLGN--------------KSMSTSTSTNEADDVSKSDTYE 869
                     ..|.||:..:..|.||.:..              :.:...:....|||:    .|:
Frog  1032 ---------SGEEQAVYVRVTNTKLGISTMWSQGKFEEKLVCMRELYQGSFEGNADDL----FYD 1083

  Fly   870 TCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSG 934
            ..||:. |:|.            |.||                |...:..|.:||     |...|
Frog  1084 PTDTWE-AESK------------QPSP----------------KRTRNSLSRQTS-----GLLLG 1114

  Fly   935 SGSGSVGIGGSGSAPSCTPSSQAIMSDS----------GVCLD----------SRNQAI-----L 974
            .....|.:..:..:..|   .|.::|::          |:.|.          |.|..:     |
Frog  1115 KVPTDVAVSSATFSSVC---KQLVISEAELLGKEKDFPGLILQLLTHLHEVWTSTNDVLLGYEQL 1176

  Fly   975 QNGHLNNYKQAVRTSDEDTGSCSSCE-LGRHSDVARPYCPLHSL---RRKIAAQKALIMKNLETD 1035
            :.|.|......::.|...:...:|.: |..:.:...| ||...|   .:|:....|.::...|.|
Frog  1177 EFGDLAVQPHLIKVSTAFSRMTTSAQFLDAYPEHPVP-CPQRQLLDELKKLGGSIAFLLHGCECD 1240

  Fly  1036 L------NKAQLDE-------HIADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQY 1087
            :      :|.|:::       .:..|...||.......|                 |:.|||...
Frog  1241 ITSMIKSSKKQINQSVTAIAARLGQLSVSQRLNFSRGPE-----------------EKCGMEHTE 1288

  Fly  1088 ELASSIMRSSVMSPTSMEEST-SQI 1111
            .::..|..:.:   .::|||. |||
Frog  1289 LISQKITETFI---GAVEESIGSQI 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	167/377 (44%)
		KISc	3..371	CDD:214526	167/376 (44%)
		Kinesin_assoc	370..478	CDD:292801	41/116 (35%)
		FHA	456..555	CDD:238017	34/99 (34%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
kif14l	XP_002938797.1	KISc_KIF1A_KIF1B	291..641	CDD:276816	167/375 (45%)
		Kinesin_assoc	638..756	CDD:406567	41/118 (35%)
		FHA	736..833	CDD:238017	33/96 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010