Protein Alignment Klp98A and kif14l

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_002938797.1
• Gene: kif14l / 100145032
• XenbaseID: XB-GENE-5889659
• Length: 1547
• Species: Xenopus tropicalis
• Alignment Length: 1195
• Identity: 338/1195 - (28%)
• Similarity: 558/1195 - (46%)
• Gaps: 258/1195 - (21%)

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66
            :::.|||||||.|.||:....:.:|.:..:..::..|:        .:.|..|.:|:.:||.:..
 Frog   289 TAVTVAVRVRPLNERELSSGYKCVMFVLGQTIQIQHPQ--------TNQHLSFQYDFCFWSLEPG 345

  Fly    67 DPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARM 131
            |..:|:||.||:.:...::...::|||.|:||||||||||::||||.....|:|||.|||||..:
 Frog   346 DSSYASQEVVYNQIAQPLLQGVFQGYNMCLFAYGQTGSGKSYTMMGFNEEAGIIPRFCEELFQNV 410

  Fly   132 R-VGQESGTGYRTHASYLEIYNERVKDLLAA---QSTGH-GLRVREHRSLGPYVENLSQHAVSDF 191
            . .|||. ..|....||.|||||::.|||.:   |:... .|:||||.:.||||..||.:.::.|
 Frog   411 GCTGQEE-VKYNVEMSYFEIYNEKIHDLLTSPKDQALNKVALKVREHPTFGPYVAGLSTYVIASF 474

  Fly   192 DEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA---VFMNDMPSET-VSKIHLVDLAGS 252
            .::|..:..||.||.||:|.||:.|||||::|.::..|.   :...::...| .|:::|||||||
 Frog   475 ADVQTWLELGNKQRATAATGMNEKSSRSHSVFILSVSQTMRELLEGEVHDHTRTSRVNLVDLAGS 539

  Fly   253 ERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYR 317
            ||.|:...:|.||||||.|||||:|||.|||||:|.:                 ..|:..:||||
 Frog   540 ERCNSAQTSGVRLKEGASINKSLLTLGKVISALSEMS-----------------EVKKRSFIPYR 587

  Fly   318 DSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIREL 382
            ||:|||||::||||||||.|||.:|||..|..|:|||||||::|:||||...||||:...|||||
 Frog   588 DSLLTWLLRESLGGNSKTAMIATVSPATVNLEESLSTLRYASQARNIINVARVNEDSTAALIREL 652

  Fly   383 REEINKLKS----MLAGDIHSLQPSLKVLADLQKK-EAQEKVLTE---EWTEKWKVAQSILQEQK 439
            :.||:|||:    :...|..:...||..:..|::: ..|||.|||   .|.||.::|:. .:|::
 Frog   653 KAEIDKLKAAQQCVQGVDQETYDASLHEIQSLRERLFIQEKELTETQKSWEEKLELAKQ-QKEEE 716

  Fly   440 SLGLRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQ 503
            :..|:|:||...:|:.:|:|:.::.| ..:.|.||.:|:|:|.:|.:......:|:|.|..|...
 Frog   717 AKELQKAGVCFKVDNMLPNLVNLNEDPQLSEVLLYIIKKGQTMVGKQHPGSDHEIQLTGALIAEN 781

  Fly   504 HCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSR 568
            ||.|..|.|.|:|.|.|.|:.::|.:|:..|..:..||.::||..:.||||:|.|...:|:.:..
 Frog   782 HCLINNKAGQVSLTPLPDAETFINGNLVRNPIVLHHGDRVILGGNHYFRFNHPTEVDSVRRSVMP 846

  Fly   569 SQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRK----IL 629
                                   :::::|...::..:.:.. :....|.:.|::|...:    ::
 Frog   847 -----------------------HTNQEGPRDFEFAKNELI-EAQTQRIENEIEDARLQAQTDMM 887

  Fly   630 DTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLL--NCREQELIARKDML--- 689
            ..::.|.:...:|..|..:.|:.::|:|..||    :||::..:.:  :.:|......:|.|
 Frog   888 KELQAAKEMAQMELTQQKNLYENRIRQLEREL----EEELERKRSIKRSLKESRPATGRDHLPPS 948

  Fly   690 -LWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLND 753
             |:   ::.|::.|   :.|.|...|:.:|    |.:..:::::|..||......|..:.|.|..
 Frog   949 GLY---SQGVEMGI---KHSKFMQVLELEK----ETLVSQVEKMQQQGKKSISAEKQAQWTALQL 1003

  Fly   754 ELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLE 818
            .:.||.::::                             .:.:|..|. .::.|..:|
 Frog  1004 SIALQEANTI-----------------------------SKSMNKHTV-FSRYDLPVL------- 1031

  Fly   819 RLRLERAESEAESQAMRAKKQNMKLQLGN--------------KSMSTSTSTNEADDVSKSDTYE 869
                     ..|.||:..:..|.||.:..              :.:...:....|||:    .|:
 Frog  1032 ---------SGEEQAVYVRVTNTKLGISTMWSQGKFEEKLVCMRELYQGSFEGNADDL----FYD 1083

  Fly   870 TCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSG 934
            ..||:. |:|.            |.||                |...:..|.:||     |...|
 Frog  1084 PTDTWE-AESK------------QPSP----------------KRTRNSLSRQTS-----GLLLG 1114

  Fly   935 SGSGSVGIGGSGSAPSCTPSSQAIMSDS----------GVCLD----------SRNQAI-----L 974
            .....|.:..:..:..|   .|.::|::          |:.|.          |.|..:     |
 Frog  1115 KVPTDVAVSSATFSSVC---KQLVISEAELLGKEKDFPGLILQLLTHLHEVWTSTNDVLLGYEQL 1176

  Fly   975 QNGHLNNYKQAVRTSDEDTGSCSSCE-LGRHSDVARPYCPLHSL---RRKIAAQKALIMKNLETD 1035
            :.|.|......::.|...:...:|.: |..:.:...| ||...|   .:|:....|.::...|.|
 Frog  1177 EFGDLAVQPHLIKVSTAFSRMTTSAQFLDAYPEHPVP-CPQRQLLDELKKLGGSIAFLLHGCECD 1240

  Fly  1036 L------NKAQLDE-------HIADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQY 1087
            :      :|.|:::       .:..|...||.......|                 |:.|||...
 Frog  1241 ITSMIKSSKKQINQSVTAIAARLGQLSVSQRLNFSRGPE-----------------EKCGMEHTE 1288

  Fly  1088 ELASSIMRSSVMSPTSMEEST-SQI 1111
            .::..|..:.:   .::|||. |||
 Frog  1289 LISQKITETFI---GAVEESIGSQI 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	167/377 (44%)
		Kinesin_assoc	370..478	CDD:465047	41/116 (35%)
		FHA_KIF16	449..556	CDD:438760	36/107 (34%)
		SMC_N	624..>864	CDD:481474	42/263 (16%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
kif14l	XP_002938797.1	KISc_KIF1A_KIF1B	291..641	CDD:276816	167/375 (45%)
		Kinesin_assoc	638..756	CDD:465047	41/118 (35%)
		FHA_KIF14	727..834	CDD:438759	36/106 (34%)