Protein Alignment Cyp6a18 and ERG11

DIOPT Version :9

• Sequence 1: NP_001287562.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 539
• Identity: 137/539 - (25%)
• Similarity: 223/539 - (41%)
• Gaps: 106/539 - (19%)

  Fly     3 LTYFL---FQVAVALLAIVTYILH--RKLTYFKRRGIPYDKPH------PLRGN--MEGYKKTRT 54
            |::||   ....::|:.|:.:|.:  .:|.|..|:    |:|.      |..|:  :.|.|.
Yeast    19 LSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRK----DRPPLVFYWIPWVGSAVVYGMKP--- 76

  Fly    55 VHEIHQEYYNKYRNSKAPFV------GFYLFQKPAAFVIDLELAKQILIKNFSNFT----DKGIY 109
             :|..:|...||.:..: ||      ..||..|...||.:.:||.......:::.|    .||:.
Yeast    77 -YEFFEECQKKYGDIFS-FVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVI 139

  Fly   110 YNEKDDPMSAHLFNLDGPQWRLLRSK--LSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSI 172
            |              |.|..||:..|  :....|....|...|.   :|||......:  |:|..
Yeast   140 Y--------------DCPNSRLMEQKKFVKGALTKEAFKSYVPL---IAEEVYKYFRD--SKNFR 185

  Fly   173 LDVRDLVARFTVDVIGT----CAFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRS---- 229
            |:.|   ...|:||:.|    ..|....:.|..|        .||.||:....|.|.|.:.
Yeast   186 LNER---TTGTIDVMVTQPEMTIFTASRSLLGKE--------MRAKLDTDFAYLYSDLDKGFTPI 239

  Fly   230 ---YPNLARRLGLCRNTAQ--IQEFYQRIVKETVTLREKENIKRNDFMDMLIGLKNQKNMTLENG 289
               :|||.......|:.||  |...|..::||.   |:..:|:..|.:|.|:     ||.|.::|
Yeast   240 NFVFPNLPLEHYRKRDHAQKAISGTYMSLIKER---RKNNDIQDRDLIDSLM-----KNSTYKDG 296

  Fly   290 EVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYE 354
              || :|..||........:.|..||::|..:.|..||:.|.:|.::..|..:||:...::.||:
Yeast   297 --VK-MTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYD 358

  Fly   355 CIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPE 419
            .::::..|:|.|.||||.:..:.::.|...|...|| |..:||.||..|::.....|.....:|.
Yeast   359 LLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVP-NTSYVIPAGYHVLVSPGYTHLRDEYFPN 422

  Fly   420 PNEFRPERFSPEES----------------AKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAML 468
            .::|...|::.:.:                :|..|..:||||.|...|||..|...|..:.:::.
Yeast   423 AHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIF 487

  Fly   469 IKNFTFS-PCSATPDPLTF 486
            |:...:. |...|..|..|
Yeast   488 IRTLKWHYPEGKTVPPPDF 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	127/499 (25%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	120/467 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I1492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1477
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960