DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	459	Identity:	124/459 - (27%)
Similarity:	218/459 - (47%)	Gaps:	52/459 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GFYLFQKPAAFVIDLELAKQILIKNFSNFT------DKGIYYNEKDDPMSAHLFNLDGPQWRLLR 133
            ||.::..|.:.:  |.|....:|::..|.:      || .:|:..:..:...|....|.:|...|
Human    87 GFKVWMGPISPL--LSLCHPDIIRSVINASAAIAPKDK-FFYSFLEPWLGDGLLLSAGDKWSRHR 148

  Fly   134 SKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK----VSENS-ILDVRDLVARFTVDVIGTCAFG 193
            ..|:..|....:|    ..:.:..|.:.:||.|    .||.| .||:.:.::..|:|.:..|.|.
Human   149 RMLTPAFHFNILK----PYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFS 209

  Fly   194 IKCNSLRDEKAEFLH--FGRRALLDSRHGNLVSGLMRSY---PNLARRLGLCR-----NTAQIQE 248
            .. :..:::.:|::.  ....||:..||..::..:...|   |:..|....||     ..|.|||
Human   210 FD-SHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQE 273

  Fly   249 FYQRIVKETVT--LREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAG 311
            ..:.:..:.|.  |:.|...|..||:|:|:..|:      |:|   |.|:.::|.|:|..|...|
Human   274 RRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD------EDG---KKLSDEDIRAEADTFMFEG 329

  Fly   312 FDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQK-FTYECIKDLKYLDQVINETLRHYTI 375
            .||::|.:.:.||.|||:|..|::.|.|:.::|:..:.| ..::.:..|.:|...:.|:||.:..
Human   330 HDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPP 394

  Fly   376 VPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVA 440
            ||.:.|...:..|:|...  ||..|...:|.....||:|:::|:|..:.|.||.||...:|..:|
Human   395 VPVISRHVTQDIVLPDGR--VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLA 457

  Fly   441 WLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP--DPLTFDPHSAILLGIKGGIQLK 503
            ::||..|||||||..|...:.::.||:.:..|...|....|  .|       .::|..:||:.|:
Human   458 FIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKP-------ELVLRAEGGLWLR 515

  Fly   504 VEAI 507
            ||.:
Human   516 VEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	122/454 (27%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	121/453 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810