DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	548	Identity:	146/548 - (26%)
Similarity:	243/548 - (44%)	Gaps:	105/548 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAIVTYILHRKL--TY------FKRRGIPYDKPHPLRG-----------NMEGYKKTRTVHEIH 59
            ||...::||.|.|  ||      .:.|..|  :| |.|.           |.||   .:.:.|..
Mouse    23 LLGAASWILARILAWTYSFCENCSRLRCFP--QP-PKRNWFLGHLGMIEHNEEG---MQLMTEAG 81

  Fly    60 QEYYNKYRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNF-------TDKGIYYNEKDDPM 117
            |.|.:.:.....|.:.......| |||..|.||..::....:.|       ...|::.|
Mouse    82 QTYRDVHLCWLGPVIPVLRIVDP-AFVAPLLLASALVAPKDTTFHTFVKPWLGDGLFLN------ 139

  Fly   118 SAHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK----VSENSI-LDVRD 177
                   .|.:|...|..|:..|....:|    ..|.:..:.:.:||.|    .||.|. |::.:
Mouse   140 -------SGDKWSRHRRLLTPAFHFDILK----PYVKIFNQSVNIMHAKWKHLSSEGSARLEMFE 193

  Fly   178 LVARFTVDVIGTCAFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRN 242
            .::..|:|.:..|.||...| .::..:|::    .|:|:.  .:||  :.||:........|..:
Mouse   194 HISLMTLDSLQKCLFGFDSN-CQESPSEYI----SAILEL--SSLV--IKRSHQLFLFVDFLYYH 249

  Fly   243 TAQ----------IQEFYQRIVKE---TVT-------LREKENIKRNDFMDMLIGLKNQKNMTLE 287
            ||.          :..|...:::|   |::       |:.|...|..||:|:|:..|:      |
Mouse   250 TADGRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAKD------E 308

  Fly   288 NGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLE-QHDQKF 351
            :|   |.|:.::|.|:|..|...|.||::|.:.:.||.||::|..|::.|.|:.::|. :..|:.
Mouse   309 HG---KELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEI 370

  Fly   352 TYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSI 416
            .::.:..|.:|...|.|:||.:..|.::.|...:..|:|...  ||..|...:|....|||:||:
Mouse   371 EWDDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGR--VIPKGNICVISIFGIHHNPSV 433

  Fly   417 YPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP 481
            :|:|..:.|.||.||.:.|||.:|::||..|||||||..|...:..:.||:.:..|...|....|
Mouse   434 WPDPEVYDPFRFDPENAHKRPPLAFIPFSAGPRNCIGQTFAMNEMMVALALTLLRFRILPDDKEP 498

  Fly   482 --DPLTFDPHSAILLGIKGGIQLKVEAI 507
              .|       .|:|..:||:.|:||.:
Mouse   499 RRKP-------EIILRAEGGLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	134/511 (26%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	127/485 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900