DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp4a31

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_964002.2	Gene:	Cyp4a31 / 666168	MGIID:	3028580	Length:	509	Species:	Mus musculus

Alignment Length:	542	Identity:	135/542 - (24%)
Similarity:	227/542 - (41%)	Gaps:	98/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKA 71
            :|.:.:.|:..|...||||......:..|....|...|: |.:|..:.:    ||..:...|..:
Mouse    24 VFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGH-EQFKGDQEL----QEIVSCIENFPS 83

  Fly    72 PFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDP------------MSAHLFNL 124
            .|..::...|....|.|.:..|.||               .:.||            :...|..|
Mouse    84 AFPRWFWGSKAYLTVYDPDYMKVIL---------------GRSDPKANGAYRLLAPWIGYGLLLL 133

  Fly   125 DGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK----VSENSILDVRDLVARFTVD 185
            :|..|...|..|:..|....:|    |.|....:.:.:|.:|    ..::|.:::...::..|:|
Mouse   134 NGQSWFQHRKMLTPAFHYDILK----TYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISLMTLD 194

  Fly   186 VIGTCAFGIKCNSLRDEKAE-FLHFGRRALLDSRHGNLVSGLMRS--YPN-----LARRLGLCRN 242
            .:..|||..|.:...|...: :|    :|:.|.  .|||...:|:  :.|     |:....|...
Mouse   195 TVMKCAFSHKGSVQVDGNYKTYL----QAIGDL--NNLVHSRVRNMFHQNDTIYKLSSNGRLSNQ 253

  Fly   243 TAQI-QEFYQRIVKETVTLR--------EKENIK---RNDFMDMLIGLKNQKNMTLENGEVVKGL 295
            ..|: .:....::|    :|        |.||||   |.||:|:|:..:      :||.:   .:
Mouse   254 ACQLAHDHTDGVIK----MRKDQLQDEGELENIKKKRRLDFLDILLFAR------MENED---SM 305

  Fly   296 TMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLK 360
            :..::.|:...|.|.|.||::|.:.:..|.||.:|..|.:.|.|: |.|.......|::.:..:.
Mouse   306 SDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEV-QSLLGDGSSITWDHLDQIP 369

  Fly   361 YLDQVINETLRHYTIVPNVDRVAAKRFVVPGN---PKFVIEAGQSVIIPSSAIHHDPSIYPEPNE 422
            |....|.|.||.|..||::.|..:.....|..   ||     |..|.:....:||:|.::|.|..
Mouse   370 YTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPK-----GVQVTLSIYGLHHNPKVWPNPEV 429

  Fly   423 FRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFD 487
            |.|.||:|:  :.|.|.::|||..|.|||||.:|...:.::.:|:.:..|     ...||| |..
Mouse   430 FDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRF-----ELLPDP-TRV 486

  Fly   488 PHS--AILLGIKGGIQLKVEAI 507
            |.|  ..:|..|.||.|.::.:
Mouse   487 PMSLARFVLKSKNGIYLHLKKV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	127/506 (25%)
Cyp4a31	NP_964002.2	p450	52..503	CDD:278495	127/507 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900