DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	400	Identity:	106/400 - (26%)
Similarity:	197/400 - (49%)	Gaps:	39/400 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 GPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFM--AVMHEKVSENSILDVRDLVARFTVDVIG 188
            |.:|...|..|:..|....:| .|.|:.:.:...|  ...|.....:|.||:.:.::..|:|.:.
Human   141 GDKWSRHRRMLTPAFHFNILK-SYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQ 204

  Fly   189 TCAFGIKCNSLRDEKAEFLH--FGRRALLDSRHGNLVSGLMRSY--PNLARRL-GLCRNTAQIQE 248
            .|.|... :..::..:|::.  ....||::.|..:::..:...|  .:..||. ..||   .:.:
Human   205 KCIFSFD-SHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACR---LVHD 265

  Fly   249 FYQRIVKE---TVT-------LREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQ 303
            |...:::|   |:.       .::|...|..||:|:|:..|:      |:|   |.|:.::|.|:
Human   266 FTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD------EDG---KALSDEDIRAE 321

  Fly   304 AFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQK-FTYECIKDLKYLDQVIN 367
            |..|...|.||::|.:.:.||.||::|..|::.|.|:.::|:..|.| ..::.:..|.:|...:.
Human   322 ADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVK 386

  Fly   368 ETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEE 432
            |:||.:...|.:.|...:..|:|...  ||..|.:.:|....:||:|:::|:|..:.|.||.||.
Human   387 ESLRLHPPAPFISRCCTQDIVLPDGR--VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPEN 449

  Fly   433 SAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIK 497
            |..|..:|::||..|||||||..|...:.::.||:::.:|.|.|....|     .....:::..:
Human   450 SKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEP-----RRKLELIMRAE 509

  Fly   498 GGIQLKVEAI 507
            ||:.|:||.:
Human   510 GGLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	104/395 (26%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	101/385 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810