Protein Alignment Cyp6a18 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 163/519 - (31%)
• Similarity: 254/519 - (48%)
• Gaps: 59/519 - (11%)

  Fly    10 VAVALLAIVTYILH-RKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAPF 73
            ||.:|:.:..|..| .||  ||:.|||...|.|..|.:..|  .|.:....:|...||    ...
Human    15 VATSLVLLYIYGTHSHKL--FKKLGIPGPTPLPFLGTILFY--LRGLWNFDRECNEKY----GEM 71

  Fly    74 VGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK---GIYYNEKDDPM----SAHLFNLDGPQWR 130
            .|.|..|:|...::|.::.|.:|:|. :|.||::   |        ||    ||..|..| .:|:
Human    72 WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG--------PMGFLKSALSFAED-EEWK 127

  Fly   131 LLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIK 195
            .:|:.||..|||.|.|.|.|.:....:..:..:.::...:..::::|....:|:|||....||:.
Human   128 RIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192

  Fly   196 CNSLRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNL-----ARRLGLCRNTAQIQEFYQRIV 254
            .:||.:.:..||...::.| ||.....|:  |:..:|.|     |..:||.  ...:..|.:..:
Human   193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLL--LISLFPFLTPVFEALNIGLF--PKDVTHFLKNSI 253

  Fly   255 KETVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSST 318
            :.....|.|:..| |.||...:|..:|.|.....     |.|:..|:|||:.:...|.:||:|:|
Human   254 ERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSH-----KALSDLELVAQSIIIIFAAYDTTSTT 313

  Fly   319 MGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVA 383
            :.|.:||||.:|.:|.|::.|:..|| .:....||:.:..::|||.|:|||||.:.:|..|.||.
Human   314 LPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377

  Fly   384 AKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPE-RFSPEESAKRPSVAWLPFGEG 447
            .|...:.|   ..|..|.:|::|..|:||||..:.||.:|.|| |||.:.........::|||.|
Human   378 KKDIEING---VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAG 439

  Fly   448 PRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFD------PHSAILL------GIKGG 499
            ||||||:||.....::.:...::||:|.||..|..||..|      |...|:|      ||..|
Human   440 PRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSG 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	143/458 (31%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	141/451 (31%)