Protein Alignment Cyp6a18 and Cyp3a57

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_001093650.1
• Gene: Cyp3a57 / 622127
• MGIID: 3646373
• Length: 503
• Species: Mus musculus
• Alignment Length: 511
• Identity: 154/511 - (30%)
• Similarity: 260/511 - (50%)
• Gaps: 57/511 - (11%)

  Fly    15 LAIVTYIL--------HRKLTY----FKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYR 67
            |:|.|::|        :...||    ||:.|||..||.||.||:..|  ...:.:...:.|.||
Mouse     7 LSIQTWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNIINY--LDGMWKFDDDCYKKY- 68

  Fly    68 NSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK----GIYYNEKDDPMSAHLFNLDGP 127
               ....|||...:|...::|.|:.|.:|:|. :|.||::    .:.:.:|...:|      :..
Mouse    69 ---GKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPFGPVGFLKKSITIS------EDE 124

  Fly   128 QWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAF 192
            :|:.||:.||.||||.|:|.|:|.:....:..:..:..:..:...::::|:...:::|||...:.
Mouse   125 EWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGAYSMDVITGTSC 189

  Fly   193 GIKCNSLRDEKAEFLHFGRRAL----LDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFY 250
            |:..:||.:.:..|:...::.|    .|.   .|:|.::  :|.|.   ..|.|.....|...|:
Mouse   190 GVNIDSLNNPQDPFVQKIKKILKFKFFDP---FLLSVVL--FPFLTPIYEMLNLSIFPRQSMNFF 249

  Fly   251 QRIVKETVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDT 314
            ::.||:....|...|.| |.||:.:::..:|.|..     |.:|.|:..|:.||..:|...|:|.
Mouse   250 KKFVKKMKKDRLDYNQKNRVDFLQLMMNTQNSKGQ-----ESLKALSDLEMAAQTLIFIFGGYDG 309

  Fly   315 SSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNV 379
            :|:::.|.:||||.:|.:|.|::.|:.:.| .:....||:.:.|::|||.|:||:||.|.:|..:
Mouse   310 TSTSISFIMYELATHPDVQKKLQDEIDRAL-PNKAPVTYDALMDMEYLDMVVNESLRLYPVVSRI 373

  Fly   380 DRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPF 444
            ||.:.|...:.|   ..|..|..|:||...:|.||..:|||.:|.|||||.|.........::||
Mouse   374 DRFSKKDVEIHG---VFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPF 435

  Fly   445 GEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILL 494
            |.|||||||:||..:..::.:..:::|||..||..|..|:      .|.|...|:|
Mouse   436 GNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQIPVKISRQPIFRPEKPIIL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	133/444 (30%)
Cyp3a57	NP_001093650.1	cytochrome_P450	67..492	CDD:477761	135/449 (30%)