DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	405	Identity:	108/405 - (26%)
Similarity:	198/405 - (48%)	Gaps:	49/405 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 GPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK----VSENSI-LDVRDLVARFTVD 185
            |.:|...|..|:..|....:|    ..:.:..:.:.:||:|    .||.|. ||:.:.::..|:|
Human   141 GDKWSRHRRMLTPAFHFNILK----PYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLD 201

  Fly   186 VIGTCAFGIKCNSLRDEKAEFLH--FGRRALLDSRHGNLV---SGLMRSYPNLARRLGLCRNTAQ 245
            .:..|.|..:.| .:::.:|::.  ....|.::.|:..::   ..|....|:..|....|.   .
Human   202 SLQKCVFSFESN-CQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACH---L 262

  Fly   246 IQEFYQRIVKE---TVT-------LREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEI 300
            :.:|...:::|   |:.       |:.|...|..||:|:|:..|:      |:|   |.|:.::|
Human   263 VHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD------EDG---KELSDEDI 318

  Fly   301 VAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQ-KFTYECIKDLKYLDQ 364
            .|:|..|...|.||::|.:.:.||.|||:|..|::.|.|:.::|:..:. :..::.:..|.:|..
Human   319 RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTM 383

  Fly   365 VINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFS 429
            .|.|:||.:..||.:.|...:.||:|...  ||..|...:|....||::|:::|:|..:.|.||.
Human   384 CIKESLRLHPPVPVISRCCTQDFVLPDGR--VIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFD 446

  Fly   430 PEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP--DPLTFDPHSAI 492
            .|...:|..:|::||..|||||||..|...:.::.||:.:.:|...|....|  .|       .:
Human   447 QENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKP-------EL 504

  Fly   493 LLGIKGGIQLKVEAI 507
            :|..:||:.|:||.:
Human   505 ILRAEGGLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	106/400 (27%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	102/390 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810