DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	508	Identity:	150/508 - (29%)
Similarity:	253/508 - (49%)	Gaps:	40/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            |:.|...::.|..|.....|   ..||:.|||..||.||.|.:..|..  .:.:..::.|.||
Mouse    11 TWVLLVTSLVLFYIYGTYSH---GLFKKLGIPGPKPLPLLGTIFNYYD--GMWKFDEDCYKKY-- 68

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIY----YNEKDDPMSAHLFNLDGPQ 128
              ....|||...:|...::|.|:.|.:|:|. :|.||::..:    :.:|...:|      :..:
Mouse    69 --GKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMKKAITIS------EDEE 125

  Fly   129 WRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFG 193
            |:.||:.||.||||||:|.|:|.:....:..:..:..:..:...:.::|:...:::|||...:||
Mouse   126 WKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFG 190

  Fly   194 IKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIVK 255
            :..:||.:.:..|:...::.|........:..:: .:|.|.   ..|...........|:::.||
Mouse   191 VNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSII-LFPFLTPIYEMLNFSIFPRDSMNFFKKFVK 254

  Fly   256 ETVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTM 319
            .....|...|.| |.||:.:::..:|.|..     |..|.|:..|:.|||.:|...|:|.:|:::
Mouse   255 RMKKERLASNQKNRVDFLQLMMNTQNSKGQ-----ESQKALSDLEMAAQAVIFIFGGYDATSTSI 314

  Fly   320 GFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAA 384
            ...:||||.:|.:|.|::.|:.:.| .:....||:.:.|::|||.|:||:||.|.|...::||:.
Mouse   315 SLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSK 378

  Fly   385 KRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPR 449
            |...:.|   ..|..|..|:||...:|.:|..:|||.||.|||||.|.........::|||.|||
Mouse   379 KDVEING---VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGNGPR 440

  Fly   450 NCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILLGI 496
            ||||:||..:..::.:..:::|||..||..|..||      .|.|...|:|.:
Mouse   441 NCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEKPIILKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	140/474 (30%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	141/475 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720