DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	532	Identity:	134/532 - (25%)
Similarity:	234/532 - (43%)	Gaps:	78/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AVALLAIVTYILHRKLTYF----KRRGIP-YDKPHPLRGNMEGYKKTRTVHEIHQEYYNKY---- 66
            ||.||.:.:...:....|.    :.|.|| ....:|:.||...:|...      .:::|:.
Zfish    16 AVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNA------GDFFNQIIEGT 74

  Fly    67 -RNSKAPFVGFYLFQKPAAFVIDLELAKQI-LIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQW 129
             .|...|....::  .|..|:| |..|:.| ::.:.|...||...|......:...|....|.:|
Zfish    75 NENRHLPLAKVWV--GPVPFLI-LYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTSTGEKW 136

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHE----------KVSENSILDVRDLVARFTV 184
            |..|..|:.||.           .|:..:|:.||:|          |:.:....:..:.:....:
Zfish   137 RNRRKMLTPTFH-----------FSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCAL 190

  Fly   185 DVIGTCAFGIKCNSLRDEKAEFLH--FGRRALLDSRH------GNLVSGLMRSYPNLARRLGLCR 241
            |:|...|.|.|..:..:..:|::.  :....::..|.      .:.:...::.....|:||.:
Zfish   191 DIICETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKI-- 253

  Fly   242 NTAQIQEFYQRIVKETVTLREKE--------NIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMD 298
                :..|...:::|.......|        ..||..|:|||:      ..|.|||:   .|:.:
Zfish   254 ----LHSFTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLL------KTTYENGQ---KLSHE 305

  Fly   299 EIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLD 363
            :|..:...|...|.||::::|.:||:.:..:|.:|..|:|||.:|....::....|.:|.|:||:
Zfish   306 DIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGVEDLKKLRYLE 370

  Fly   364 QVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERF 428
            .||.|:||.:..||...|...:...:.|   |.:..|.:.:|...|:|.||..:|||.||:||||
Zfish   371 CVIKESLRIFPSVPLFARSICEACHING---FKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERF 432

  Fly   429 SPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAIL 493
            .||.|..|...|::||..|||||||.||..|:.::.||.::::|....|.:..:   ..|...::
Zfish   433 MPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREE---LRPLGELI 494

  Fly   494 LGIKGGIQLKVE 505
            |..:.||.:|::
Zfish   495 LRPEKGIWIKLQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	125/497 (25%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	126/501 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810