DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	533	Identity:	135/533 - (25%)
Similarity:	224/533 - (42%)	Gaps:	80/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VAVALLAIVTY-----ILHRKLTYFKRRGIP-YDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            |.|...|.:||     .||:   :.:.:.|| .....|..||...:|...........|..:::|
Zfish    17 VCVICFAYITYQLLKSYLHK---WKELKPIPGIGNTFPFIGNALQFKSNGDFFLQLVGYTTEFQN 78

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLR 133
            |  |.:..::...|...:...|..:.:|  |.....||...|......:...|....|.:||..|
Zfish    79 S--PLLKIWIGPIPFLILFHAETVETVL--NNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRR 139

  Fly   134 SKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDV---IGTCAFGIK 195
            ..|:.||.           .|:..||:.||:|: :|..|..:.....:...:.   |..||..|.
Zfish   140 KMLTPTFH-----------FSILTEFLEVMNEQ-AEVLIEKLEKQAGKGPFNCFSHITLCALDII 192

  Fly   196 CNSLRDEKAEFLHFGRRALLDSRH-GNLVSGLMRSYPNLARRLGL------------------CR 241
            |.:.         .|:|....|.: ...|..:.|....:.||..:                  .|
Zfish   193 CETA---------MGKRIYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNR 248

  Fly   242 NTAQIQEFYQRIVKET---VTLREKEN------IKRNDFMDMLIGLKNQKNMTLENGEVVKGLTM 297
            :...:..|.:.::.|.   ::..|.::      .||..|:|||:..|:      |:|   |.||.
Zfish   249 SLKILHSFTESVINERAEYLSYVESDSESDQGMRKRRAFLDMLLKTKD------EDG---KMLTH 304

  Fly   298 DEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYL 362
            .:|..:...|...|.||:::.|.:|::.|..:|.:|.|.:.||.:|..:.::....|.:|.|:||
Zfish   305 KDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESERPVNTEDLKKLRYL 369

  Fly   363 DQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPER 427
            :.||.|:||.:..||...|.......:.|   |.:..|.::::.:.|:|.||..:|:|.||||||
Zfish   370 ECVIKESLRLFPSVPFFARTICDDTQING---FKVPKGTNIVVITYALHRDPRFFPDPEEFRPER 431

  Fly   428 FSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAI 492
            |.||....|...|::||..|.|||||.||..|:.::.||.:::.|....|....:   ..|...:
Zfish   432 FLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQKREE---LRPLGEL 493

  Fly   493 LLGIKGGIQLKVE 505
            :|..:.||.:.:|
Zfish   494 VLRPEQGIWITLE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	125/496 (25%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	124/496 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810