DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	515	Identity:	159/515 - (30%)
Similarity:	267/515 - (51%)	Gaps:	46/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLTYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNK 65
            :.:|:.|..:.:.||.|.....||   :|.:.|||..:|.|..|.:..|.|  .:.....|...|
Zfish     7 LSVTWTLVVLVITLLFIYGVWPHR---FFIKLGIPGPRPWPFVGTLLSYAK--GLCNFDMECAKK 66

  Fly    66 YRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDPMSAHLFNLDGPQW 129
            |    ....|.|..:.|...|.|||:.|.:|:|. :|||.::.........|.|..:..:...:|
Zfish    67 Y----GKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERW 127

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGI 194
            :.:||.||..||||::|.::|..::.|:.|:..|.:|..|..: .::::||.:::|||.:.:|.:
Zfish   128 KRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQPV-KIKEVVAPYSLDVITSSSFSV 191

  Fly   195 KCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIVKE 256
            ..:|:.:.:..|: ...:..:.....|.:..|:..:|:||   :::|:...:....:|:..::|:
Zfish   192 DIDSINNPEDPFV-INVKKFIQFNMFNPLLLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKK 255

  Fly   257 TVTLREKENIKRNDFMDMLIGLKN-------QKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDT 314
            ......||:..|.||:.::  |:|       |.:.|.|  :..||||..||::|:.||.:.|::|
Zfish   256 IKDDHNKESEGRVDFLKLM--LQNQIPDDQIQDSDTSE--QPAKGLTDHEILSQSLVFILGGYET 316

  Fly   315 SSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKF------TYECIKDLKYLDQVINETLRHY 373
            :|:|:.|.||.||.||...:|       ::|:.|:.|      ||:.:..:.||:..|||::|..
Zfish   317 TSTTLTFLLYNLATNPDCLEK-------LVEEIDKNFPLDTPITYDALMRMDYLEMAINESMRLL 374

  Fly   374 TIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPS 438
            ...|.::|.|.|..|:.|   ..|..|..|.||:..:.|||.|:..|.||||||||||..::...
Zfish   375 PTAPRLERSAKKTVVING---LTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQ 436

  Fly   439 VAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL----TFDPHSAILL 494
            .|::|||.|||||||:|:..|..::.:..|::||:...|..|..||    ||.|...|.|
Zfish   437 YAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNVTFQPKVPITL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	148/478 (31%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	144/468 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.720