DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	504	Identity:	146/504 - (28%)
Similarity:	262/504 - (51%)	Gaps:	42/504 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLTYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNK 65
            :.:|:.|..:.:.||.:.....|   .:||:.|||..:|.|..|....|  |:.......|...|
Zfish     7 LSVTWILVVLVLTLLYMYGVWPH---GFFKKLGIPGPRPWPFFGTFLSY--TKGFFNFDMECAKK 66

  Fly    66 YRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDPMSAHLFNLDGPQW 129
            |    ....|.|..:.|...|.|||:.|.|::|. :|.||::.....:...|::..:..:...:|
Zfish    67 Y----GKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAVKDERW 127

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGI 194
            :.:|..||..||||::|.::|..::.|:.|:..| :|......:.:::::|.:::||:.:.||.:
Zfish   128 KRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNM-QKGDHEQPVKIKEVMASYSLDVVTSSAFSV 191

  Fly   195 KCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYP---NLARRLGLCRNTAQIQEFYQRIVKE 256
            ..:|:.:....|:...:..|..:..|..|. |:..:|   ||..::||...:....:|:.:.:::
Zfish   192 DIDSINNPDDPFVTNIKNFLKFNLFGLFVL-LLTVFPSIANLLGKMGLSMFSKPTVDFFYKALRK 255

  Fly   257 TVTLREKENIKRNDFMDMLIGLKNQ------KNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTS 315
             :....|::..|.||..::|  :|:      |:.|.|..|  ||||..||::|:|:|.:.|::|:
Zfish   256 -IKEEHKDSNGRVDFFRLMI--QNEIPDDQVKDTTSEQPE--KGLTDHEILSQSFIFIMGGYETT 315

  Fly   316 SSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKF------TYECIKDLKYLDQVINETLRHYT 374
            |:|:.|.||.||.||...:|       ::|:.|:.|      :|:.:..:.||:..|||::|...
Zfish   316 STTLTFLLYNLAINPDCLEK-------LVEKIDKNFPLDTPISYDALMKIDYLEMSINESMRLLP 373

  Fly   375 IVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSV 439
            ..|.::||..|...:.|   ..|.....:.||:..::.||.::..|:||||||||||..::....
Zfish   374 TAPRLERVCKKTVEMNG---ITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQY 435

  Fly   440 AWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDP 488
            |::|||.|||||||:|:..|..::.:..|::||:...|..|..||..:|
Zfish   436 AFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLELNP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	136/467 (29%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	137/470 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910