Protein Alignment Cyp6a18 and cyp3a4.2

DIOPT Version :9

• Sequence 1: NP_001287562.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_001015786.1
• Gene: cyp3a4.2 / 548503
• XenbaseID: XB-GENE-971750
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 520
• Identity: 153/520 - (29%)
• Similarity: 257/520 - (49%)
• Gaps: 65/520 - (12%)

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            |:.|  :|..|:.|:.|.:. ...|||:.|||...|.|..|....::|...  :...|.:.||
 Frog    11 TWIL--LAALLVLILLYGIW-PYGYFKKMGIPGPTPLPFIGTFLEFRKGMV--QFDTECFKKY-- 68

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDPMSAHLFNLDGP----- 127
              ....|.|..::|...::|..:.|.||:|. ::|||::             ..|.|:||
 Frog    69 --GKMWGTYDGRQPVLAIMDPAIIKTILVKECYTNFTNR-------------RNFGLNGPFESAI 118

  Fly   128 ------QWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDV 186
                  ||:.:|:.||.||||||:|.|:..:...::..:..:...|.::.....:|::..:::||
 Frog   119 TIAEDEQWKRIRNVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYVEKDEPCATKDVIGAYSMDV 183

  Fly   187 IGTCAFGIKCNSLRDEKAEF-LHFGRRALLDSRHGNLVSGLM---RSYPNLARRL-GLCRNTAQI 246
            |.:.:|.:..:||......| :|.  :.||.:   .|:|.|:   ..:|.|...| ||..|...
 Frog   184 ITSTSFSVNIDSLNKPSDPFVIHM--KKLLKT---GLLSPLLILVVIFPFLRPILEGLNLNFVP- 242

  Fly   247 QEFYQRIVKETVTLREK----ENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVF 307
            ::|.:..:....:.|||    ::..|.|.:.:::..:......|.|..  |.||..||:||:.:|
 Frog   243 KDFTEFFMNAVTSFREKRKKGDHSGRVDLLQLMMDSRTTGGNDLSNKH--KALTDAEIMAQSVIF 305

  Fly   308 FIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRH 372
            .:||::|:|:.:.:..|.||.:|.:|.::..|:...|...... ||:.:..::|||.||.||||.
 Frog   306 IVAGYETTSTALSYLFYNLATHPDVQQRLHEEIDSFLPDKASP-TYDILMQMEYLDMVIQETLRL 369

  Fly   373 YTIVPNVDRVAAKRFVVPG--NPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAK 435
            :.....::||:.:...:.|  .||.::     .:||:..:..||..:|||.||||||||.|..|.
 Frog   370 FPPAGRLERVSKQNVEINGVSIPKGIV-----TLIPAYVLQRDPEYWPEPEEFRPERFSKENRAT 429

  Fly   436 RPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTF------DPHSAILL 494
            .....:||||:||||||||||..:..::.:..|::||:..||:.|..|:.|      .|...|:|
 Frog   430 HTPFTFLPFGDGPRNCIGLRFALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIGFLQPKKPIVL 494

  Fly   495  494
             Frog   495  494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	141/486 (29%)
cyp3a4.2	NP_001015786.1	p450	39..496	CDD:365848	142/489 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2234
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9369
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060