DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	503	Identity:	148/503 - (29%)
Similarity:	260/503 - (51%)	Gaps:	40/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLTYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNK 65
            :.:|:.|..:.:.||.:.....|   .:||:.|||..:|.|..|....|  |:.......|...|
Zfish     7 LSVTWTLVFLVITLLYMYGVWPH---GFFKKLGIPGPRPWPFFGTFLSY--TKGFFNFDMECAKK 66

  Fly    66 YRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDPMSAHLFNLDGPQW 129
            |    ....|.|..:.|...|.|||:.|.|::|. :|.||::.....:...|::..:..:...:|
Zfish    67 Y----GKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERW 127

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGI 194
            :.:|..||..||||::|.::|..::.|:.|:..|.::..|..: .::::||.:::||:.:.:|.:
Zfish   128 KRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQPV-KIKEVVAPYSLDVVTSSSFSV 191

  Fly   195 KCNSLRDEKAEFLHFGRRALLDSRHGNLV--SGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKET 257
            ..:|:.:....|:...:..|..|....|:  ..|..|..||..::|:...:..|..|:...:::
Zfish   192 DIDSINNPDDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMNFFYTALRK- 255

  Fly   258 VTLREKENIKRNDFMDMLIGLKNQ------KNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSS 316
            :....|::..|.||:.::|  :||      |:.|.|  :.|||||..||::|:|:|.:.|::|:|
Zfish   256 IKDEHKDSNGRVDFLRLMI--QNQIPDDQAKDTTSE--QPVKGLTDHEILSQSFIFILGGYETTS 316

  Fly   317 STMGFALYELAKNPSIQDKVRAELGQVLEQHDQKF------TYECIKDLKYLDQVINETLRHYTI 375
            :|:.|.|:.||.||...:|       ::|:.|:.|      :|:.:..:.||:..|||::|....
Zfish   317 TTLSFLLHNLATNPDCLEK-------LVEEIDKNFPLDTPISYDALMKMDYLEMSINESMRLLPT 374

  Fly   376 VPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVA 440
            .|.::||..|...:.|   ..|.....|.||:..::.||.::..|.||||||||||..::....|
Zfish   375 APRLERVCKKTVELNG---ITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQYA 436

  Fly   441 WLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDP 488
            ::|||.|||||||:||..|..::.:..|::||:...|..|..||...|
Zfish   437 FMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	138/466 (30%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	139/469 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720