DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	128/534 - (23%)
Similarity:	238/534 - (44%)	Gaps:	95/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VAVALLA----IVTY----ILHRKLTYFKRRGIPYDKPH--PLRGNMEGYKKTRTVHEIHQEYY- 63
            |..|.||    :|||    :|.||....|.:|     |.  ||.||......|.|  ||...::
  Fly     4 VLCAFLALPLFLVTYFELGLLRRKRMLNKFQG-----PSMLPLVGNAHQMGNTPT--EILNRFFG 61

  Fly    64 --NKY-RNSKAPFVGFY---LFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLF 122
              ::| :::...::|:|   :...|.  .::..|:.|.||       .|...|:.....:...|.
  Fly    62 WWHEYGKDNFRYWIGYYSNIMVTNPK--YMEFILSSQTLI-------SKSDVYDLTHPWLGLGLL 117

  Fly   123 NLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHE----------KVSE-NSILDVR 176
            ...|.:|...|..::..|.           .::.::|..||:|          ||:: .:|.|.:
  Fly   118 TSTGSKWHKHRKMITPAFH-----------FNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQ 171

  Fly   177 DLVARFTVDVIGTCAFGIKCNSLRDEKAEFLH--------FGRRALLDSRHGNLVSGLMRSYPNL 233
            :.....|:|||...|.|:..|::.:..:..:.        ...||....:....:......||..
  Fly   172 EEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEY 236

  Fly   234 ARRLGLCRNTAQIQEFYQRIVKETVTLRE---KENIKRNDFMDMLIGLKNQKNM----TLENGEV 291
            ::.|      ..:|:|...|:.:.:.:|:   :..||.::|        ::|.|    ||.:.:|
  Fly   237 SKTL------KTLQDFTNEIIAKRIEVRKSGLEVGIKADEF--------SRKKMAFLDTLLSSKV 287

  Fly   292 -VKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQH--DQKFTY 353
             .:.||..|:..:...|...|.||::|.:|||:|.|:::|..|:|:..|...|:...  .:..|:
  Fly   288 DGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATF 352

  Fly   354 ECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYP 418
            :.|..:|:||..|.|..|.|..||.:.|...|.:|:.|:   ::..|.::.:....:.::..::.
  Fly   353 QEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGD---IVPKGTTLNLGLLMLGYNDRVFK 414

  Fly   419 EPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDP 483
            :|::|:||||..|   |.....::||..|||||||.:|..::.:..::.:|:||...|  |..:.
  Fly   415 DPHKFQPERFDRE---KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLP--ALDEL 474

  Fly   484 LTFDPHSAILLGIK 497
            ::.|.:.:..||::
  Fly   475 VSKDGYISTTLGLQ 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	116/498 (23%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	112/481 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810