DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	120/555 - (21%)
Similarity:	227/555 - (40%)	Gaps:	105/555 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYR 67
            :|.||....:..|.:......|.:.|.::  ||.....|..||      ...::..|.|.:|:
  Fly    29 ITVFLLGSILIFLVVYNKRRSRLVKYIEK--IPGPAAMPFLGN------AIEMNVDHDELFNR-- 83

  Fly    68 NSKAPFVGFYLFQK----------------PAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDP 116
                 .:|   .||                |...:.:.|..:.||  |...|.:|...|:.....
  Fly    84 -----VIG---MQKLWGTRIGINRVWQGTAPRVLLFEPETVEPIL--NSQKFVNKSHDYDYLHPW 138

  Fly   117 MSAHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVS---ENSILDVRDL 178
            :...|......:|...|..|:..|   ..|.: ...:.|..|..||:..|::   .:...::...
  Fly   139 LGEGLLTSTDRKWHSRRKILTPAF---HFKIL-DDFIDVFNEQSAVLARKLAVEVGSEAFNLFPY 199

  Fly   179 VARFTVDVIGTCAFGIKCNSLRDEKAEFLH--FGRRALLDSRHGNL------------VSGLMRS 229
            |...|:|::...|.|.:..:..:.::|::.  :|..:::.||...:            ...|.:|
  Fly   200 VTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQS 264

  Fly   230 YPNLARRLGLCRNTAQIQEFYQRIVK----ETVTLREKENIKRND---------------FMDML 275
            |.|            .:..|...:::    |...|:|..|...|:               |:|:|
  Fly   265 YIN------------TLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLL 317

  Fly   276 IGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAEL 340
            |....:       |.|   |:.::|..:...|...|.||:|:.:.:.|:.|..:|..|::|..||
  Fly   318 IDASKE-------GTV---LSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEEL 372

  Fly   341 GQVL-EQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVI 404
            ..:. :..:...|.:.:.|::||:..|.::||.:..||.:.|:..:...:.|.   ::.||...|
  Fly   373 DSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGK---IVPAGTQAI 434

  Fly   405 IPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLI 469
            |.:.|:|.:|.::|:|.:|.|:.|.||..|.|...|::||..|||||||.:|..::.:..::.::
  Fly   435 IMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVL 499

  Fly   470 KNFTFSPCSATPDPLTFDPHSAILLGIKGGIQLKV 504
            :.:.........| ||.  ...::|..|.|:::|:
  Fly   500 RKYKIEAVDRRED-LTL--LGELILRPKDGLRVKI 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	111/518 (21%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	112/521 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810