DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp6d5

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	168/488 - (34%)
Similarity:	276/488 - (56%)	Gaps:	39/488 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSK 70
            :|...||.||.:   .|....:|:.|:|.|........|.:|...|.:  .......|:.|:::|
  Fly     5 YLLIAAVTLLYV---YLKWTFSYWDRKGFPSTGVSIPFGALESVTKGK--RSFGMAIYDMYKSTK 64

  Fly    71 APFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLRSK 135
            .|.:|.||..:||..|.|.:||..:|:|:|::|.|:|:|.:||:|||||.||.::|..||.||:|
  Fly    65 EPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQMEGASWRALRNK 129

  Fly   136 LSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSI--LDVRDLVARFTVDVIGTCAFGIKCNS 198
            |:.:|||||:|.|:.|..||.::.:..:.:::..|..  |:::.|:|.:.:|:|.|..||:..:|
  Fly   130 LTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDS 194

  Fly   199 LRDEKAEFLHFGRRALLDSRHGNLVSGLMRS-----YPNLAR---RLGLCRN-TAQIQEFYQRIV 254
            ..|...||....::.     :.|.:..::|.     ||.|.:   ::|..:. |.:::|...|
  Fly   195 FADPNNEFQIISKKV-----NRNNIEDIIRGTSSFLYPGLEKFFVKIGWKQEATERMRELSNR-- 252

  Fly   255 KETVTLREKENIKRNDFMDMLIGLKNQKNM----------TLENGEVVKGLTMDEIVAQAFVFFI 309
              ||.|||:.||.|.|.:.:|:.|:||..:          :.:||  ||.::.|.|..|.|:|::
  Fly   253 --TVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNG--VKSMSKDLIAGQLFLFYV 313

  Fly   310 AGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYT 374
            ||::|::||..|.||||.:||.:.:|.:.::...:|:|..|.||:.|.|:|||:..|.||.|.|.
  Fly   314 AGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYP 378

  Fly   375 IVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSV 439
            .:|.::|:..|.:.|| :.|.||:.|..:||....:|.|...:|:|..::|||:. |........
  Fly   379 ALPLLNRICTKDYPVP-DSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYL-ENGKDYTQA 441

  Fly   440 AWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNF 472
            |:||||||||.|||.|.|::..:|.:|.::.||
  Fly   442 AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	158/456 (35%)
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	152/422 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461174
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900