DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	167/511 - (32%)
Similarity:	265/511 - (51%)	Gaps:	24/511 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALLAIVTYILHRKLT----YFKRRGIPYDKPHPLRGNMEG-YKKTRTVHEIHQEYYNKYRNSKAP 72
            ||.||...:.:|..:    :||.|||.|:||....|||.| :.:.|.:.:|..:.|.|..:.|
  Fly     7 ALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSKK-- 69

  Fly    73 FVGFYLFQKPAAFVIDLELAKQILIKNFSNFTD-KGIYYNEKDDP-------MSAHLFNLDGPQW 129
            |.|.:..::|...|.|.:|.|||.||:|.:|.: :.::....||.       ..:.||::...:|
  Fly    70 FFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARW 134

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHE---KVSENSILDVRDLVARFTVDVIGTCA 191
            :.:||.||..||..||:.|:..:..||:|.:..:.:   :|.||. ||::|...|||.|||.:.|
  Fly   135 KDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENE-LDMKDYCTRFTNDVIASTA 198

  Fly   192 FGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKE 256
            ||::.||.:|.:..|...|::....:...::...|..:...|.:.|.:.....:..:::.|:|.:
  Fly   199 FGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALKGLNKILKVELFDRKSTQYFVRLVLD 263

  Fly   257 TVTLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGF 321
            .:..|::.||.|.|.::||:..:............|:..:..:||||.||||.|||:||:..|.|
  Fly   264 AMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETSAVLMCF 328

  Fly   322 ALYELAKNPSIQDKVRAELGQVLEQHDQK-FTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAK 385
            ..:||.:|..:|.::..|:.||.:..:.| .|||.|..:||||||:||.||.:.....|||...|
  Fly   329 TAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDRECNK 393

  Fly   386 --RFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGP 448
              .|.|.|. |..::.|..:.:|:...|.||..:..|.:|.|||||.|.........:.|||.|.
  Fly   394 DITFDVDGQ-KVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFGLGQ 457

  Fly   449 RNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIKGGIQLKV 504
            |||||.||..::|:..:..|:|::.|:|...:..||.... |...|..|||..:|:
  Fly   458 RNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELIT-SGFQLSPKGGFWIKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	155/480 (32%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	155/478 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461234
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800