Protein Alignment Cyp6a18 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 113/402 - (28%)
• Similarity: 193/402 - (48%)
• Gaps: 43/402 - (10%)

  Fly   126 GPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK----VSENSI-LDVRDLVARFTVD 185
            |.:|...|..|:..|....:|    ..:.:..|.:.:||.|    .||.|. ||:.:.::..|:|
Human   141 GEKWSRHRRMLTPAFHFNILK----PYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLD 201

  Fly   186 VIGTCAFGIKCNSLRDEKAEFLH--FGRRALLDSRHGNL---VSGLMRSYPNLARRLGLCR---- 241
            .:..|.|... :..:::.:|::.  ....||:..||..:   :..|....|:..|....||
Human   202 SLQKCVFSFD-SHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHD 265

  Fly   242 -NTAQIQEFYQRIVKETVT--LREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQ 303
             ..|.|||..:.:..:.|.  |:.|...|..||:|:|:..|:      |:|   |.|:.::|.|:
Human   266 FTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD------EDG---KKLSDEDIRAE 321

  Fly   304 AFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQK-FTYECIKDLKYLDQVIN 367
            |..|...|.||::|.:.:.||.|||:|..|::.|.|:.::|:..:.| ..::.:..|.:|...|.
Human   322 ADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIK 386

  Fly   368 ETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEE 432
            |:||.:..||.|.|...:..|:|...  ||..|...:|.....||:|:::|:|..:.|.||.|:.
Human   387 ESLRLHPPVPAVSRCCTQDIVLPDGR--VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKN 449

  Fly   433 SAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP--DPLTFDPHSAILLG 495
            ..:|..:|::||..|||||||..|...:.::.|.:.:..|...|....|  .|       .::|.
Human   450 IKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKP-------ELVLR 507

  Fly   496 IKGGIQLKVEAI 507
            .:||:.|:||.:
Human   508 AEGGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	109/393 (28%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	110/396 (28%)