DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	152/510 - (29%)
Similarity:	279/510 - (54%)	Gaps:	46/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VALLAIVTYILHRKL----TYFKRRGIPYDKPHPLRGNMEG-YKKTRTVHEIHQEYYNKYRNSKA 71
            :.|..::..:|:|.:    |:::|.|:..:......|.|:. .|:.|::.....:.|.::   :.
  Fly     4 ILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARH---EG 65

  Fly    72 PFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLRSKL 136
            ..||.|:..|.:..:.|.:||:||:..:|::|.|:|:|.:|..||:||:||||.|..||.||.||
  Fly    66 KIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQKL 130

  Fly   137 SSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIKCNSLRD 201
            :.:|:|||:|.|:.|:..|.::.:..:...:.::..::::|::..:.||:||:..||::.:|.|:
  Fly   131 TPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDSFRN 195

  Fly   202 EKAEFLHFGR-----RALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKETVTLR 261
            .|.||.....     .:||...| |:...:......|..|||.   .::|....:.::|.|:..|
  Fly   196 PKNEFREISSSTSRDESLLLKIH-NMSMFICPPIAKLMNRLGY---ESRILTSLRDMMKRTIEFR 256

  Fly   262 EKENIKRNDFMDMLIGLKNQKNMTLENGEV---------VKGLTMDEIVAQAFVFFIAGFDTSSS 317
            |:.|:.|.|.:.:||.|:|...:..::.:|         :|.:::::|.||||:|::||.:::::
  Fly   257 EEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVAGSESTAA 321

  Fly   318 TMGFALYELAKNPSIQDKVRAELGQVLEQHDQK----FTYECIKDLKYLDQVINETLRHYTIVPN 378
            ...|.||||:..|.:..:.:.|:..||.:|:.|    ||||.::|||:||..|.||:|.|..:|.
  Fly   322 ASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIRKYPGLPF 386

  Fly   379 VDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLP 443
            ::|...:.:.|||. ..:|..|..::|....:..||..:|.||.:.|.||. ..:......|::|
  Fly   387 LNRECTEDYPVPGT-NHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFD-SNNMNYDQAAYMP 449

  Fly   444 FGEGPRNCIGLRFGQMQARIGLAMLIKNFTF--------------SPCSATPDPL 484
            ||||||:||.||.|::.:::.:|.::.||..              :|...|.:||
  Fly   450 FGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEPL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	146/480 (30%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	141/446 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461162
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900