DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	401/507 - (79%)
Similarity:	457/507 - (90%)	Gaps:	1/507 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLTYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNK 65
            |.|||.|||||||||||:||.:|||||||||||||:..||.:|||||..:||:.:|||.|::|||
  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65

  Fly    66 YRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWR 130
            :|.||||||||:.||.|||||||||||||||||:||||::|||:|||||||:|||||||||.|||
  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWR 130

  Fly   131 LLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIK 195
            |||:||||||||||||.|||||||||.|||.||||||.:||:|::|||||||||||||||||||:
  Fly   131 LLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGIQ 195

  Fly   196 CNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKETVTL 260
            ||||||||||||:||:|:|:|.|||.|::|.|||||.|||:||:.|....|||||.|||.|||.:
  Fly   196 CNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAV 260

  Fly   261 REKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYE 325
            ||||:|||||||||||.|||||.||||||:||:||||:|::|||||||||||:||||||||||||
  Fly   261 REKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYE 325

  Fly   326 LAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVP 390
            |||||.||||||||:.:|:|||||.|||||.||||||:||::||||.||||||:||:||||:|||
  Fly   326 LAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVP 390

  Fly   391 GNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLR 455
            |:|.||||||||||||||||||||||||||.|||||||||||||.||||||||||:|||||||||
  Fly   391 GHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLR 455

  Fly   456 FGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIKGGIQLKVEAI 507
            |||||||||||:||:||.||.||.||:||.:||.| .:||:|.||.||||.:
  Fly   456 FGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKS-FVLGVKDGIYLKVETV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	368/465 (79%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	368/464 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471786
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	12	11.800