Protein Alignment Cyp6a18 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 494
• Identity: 117/494 - (23%)
• Similarity: 215/494 - (43%)
• Gaps: 74/494 - (14%)

  Fly    10 VAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGY-KKTRTVHEIHQEYYNKYRNSKAPF 73
            |.:|.....|::...:..|....|.|  :|..|.|::..: ||......:.|:.:..:.....|.
  Rat    12 VLLAFGLCCTFVHRARSRYEHIPGPP--RPSFLLGHLPYFWKKDEACGRVLQDVFLDWAKKYGPV 74

  Fly    74 VGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLF------NLDGPQWRLL 132
            |...:|.|.:..|...|..|:.|:....|...|  .|..........||      ..|..:|...
  Rat    75 VRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSK--MYRAIQTVFGERLFGQGLVSECDYGRWYKQ 137

  Fly   133 RSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIKCN 197
            |..:...|:...:..:..|....||:.|.::..|....:.:.::|::...|:|::...|||::.:
  Rat   138 RRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETS 202

  Fly   198 SLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRL-GLCRNTAQIQE---FYQRIVKETV 258
            .|         .|.:..|......::.|:..|...||:.: |..:...:|:|   ..:::.|:.|
  Rat   203 ML---------LGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWV 258

  Fly   259 TLREKENIKRNDFM--DMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFV-FFIAGFDTSSSTMG 320
            . |.:|.:||.:.:  |:|..:...:          :|...||::...|| |||||.:||::.:.
  Rat   259 Q-RRREALKRGEDVPADILTQILKAE----------EGAQDDEVLLDNFVTFFIAGHETSANHLA 312

  Fly   321 FALYELAKNPSIQDKVRAELGQVL--EQHDQKFTYECIKDLKYLDQVINETLRHY---------- 373
            |.:.||::.|.|..:::||:.:|:  ::|   ..||.:..|:||.||:.|:||.|
  Rat   313 FTVMELSRQPEIVARLQAEVDEVVGSKRH---LDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 374

  Fly   374 ---TIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAK 435
               |::..|.        ||||        ..::..:..:....:.:.:|..|.|:||.|  .|.
  Rat   375 EEETLIDGVR--------VPGN--------TPLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAP 421

  Fly   436 RPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTF 474
            :|...:.||..|.|:|||.:|.||:.::.:|.|::...|
  Rat   422 KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	105/433 (24%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	106/443 (24%)