DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp4e3

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	121/533 - (22%)
Similarity:	237/533 - (44%)	Gaps:	70/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLFQVAVALLAIVTYILHRKLTYFKRRGIPYDK---------PHPLRGNME--GYKKTRTVHEIH 59
            :|..:|:.:|.::|      |.||:|:.....:         |.|:.||..  |......:....
  Fly     2 WLAVLALLVLPLIT------LVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFF 60

  Fly    60 QEYYNKYRNSKAPFVGFYLFQKPAAFVIDLELAKQI-LIKNFSNFTDKGIYYNEKDDPMSAHLFN 123
            ..:|:..:::...::|:      ::.:: :...||: .|.|......|...|:.....:...|..
  Fly    61 DWWYDYGKDNFLFWIGY------SSHIV-MTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLT 118

  Fly   124 LDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIG 188
            ..|.:|...|..::.:|....::..:..:...:.:||..:.:..:.::|:|.::.....|:|||.
  Fly   119 SFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVIC 183

  Fly   189 TCAFGIKCNSLRDEKAEFL--------HFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQ 245
            ..|.|:..|::....:..:        :...||....:..|.|..|...:....:.|      ..
  Fly   184 DTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTL------KT 242

  Fly   246 IQEF-YQRIVKETVTLR---EKEN------IKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEI 300
            :|:| |..|.|....|:   .||:      .|:..|:|.|:      :.|::.    :.||..||
  Fly   243 LQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLL------SSTIDG----RPLTRQEI 297

  Fly   301 VAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHD--QKFTYECIKDLKYLD 363
            ..:...|...|.||::|.:.|::|.|:::|.:|.|:..|..:|: .||  :..:::.|..:||||
  Fly   298 YEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVM-GHDMNRSVSFQEIAKMKYLD 361

  Fly   364 QVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERF 428
            ..|.|..|.|..||.:.|...|.:.:.|:   ::..|.::.:....:.::..|:.:|:.||||||
  Fly   362 LFIKEAQRVYPSVPFIGRYCDKDYDINGS---IVPKGTTLNLALILLGYNDRIFKDPHHFRPERF 423

  Fly   429 SPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAIL 493
            ..|:.|   ...:|||..|||||||.:|..::.:..::.::::|...|  |..:.::.|......
  Fly   424 EEEKPA---PFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLP--AVDELVSTDGRLNTY 483

  Fly   494 LGIKGGIQLKVEA 506
            ||:....:||.||
  Fly   484 LGLAPDEKLKREA 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	110/497 (22%)
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	104/462 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810