DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	124/515 - (24%)
Similarity:	236/515 - (45%)	Gaps:	72/515 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YFLFQVAVALLAIVTYILHRK---LTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQ--EYYN 64
            :.|..:||.::.:| :...||   :..|::..|......|:.||.......|..:.|.:  :|:|
  Fly     2 WILLGIAVLIMTLV-WDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFN 65

  Fly    65 KYRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQW 129
            ||..:    ...::..:...:..||:..:.||  :.|....|...|....|.:...|....|.:|
  Fly    66 KYGKT----FRLWILGECLIYTKDLKYFESIL--SSSTLLKKAHLYRFLRDFLGDGLLLSTGNKW 124

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSE----NSILDVRDLVARFTVDVIGTC 190
            ...|..|:..|....::    ..|.:.:....:|.||:..    .:.:|:...|:...:||....
  Fly   125 TSRRKVLAPAFHFKCLE----NFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTET 185

  Fly   191 AFGIKCNSLRDEKAEFLHFGRRAL-----LDSRHGNLVSGLMR-------SYPNLARRLGLCRNT 243
            |.|::.|:..:....:    .:||     ::|:  .|.|..||       :.|.:.|||.  ::.
  Fly   186 AMGVQVNAQNEPNFPY----TKALKSVVYIESK--RLASVSMRYNWLFPLAAPLVYRRLQ--KDI 242

  Fly   244 AQIQEFYQRIVKETVTLREKENIKRND--FMDMLIG---LKNQKNMTLENGEVVKGLTMD----- 298
            |.:|:|..::::|...:.|:   .|.|  :..:::|   :..:..|||.  :::...|:|
  Fly   243 AIMQDFTDKVIRERRAILER---ARADGTYKPLIMGDDDIGGKAKMTLL--DILLQATIDNKPLS 302

  Fly   299 --EIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVL-EQHDQKFTYECIKDLK 360
              :|..:..||..||.||::|.:..||:.::::|.:|:.:..||..|| ...|...|...:.:||
  Fly   303 DVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELK 367

  Fly   361 YLDQVINETLRHYTIVPNVDRVAAK-----RFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEP 420
            |||.||.||:|.:..||.:.|...:     ...:|||        .|:::....::.||..:|:|
  Fly   368 YLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGN--------TSILLMPYYVYRDPEYFPDP 424

  Fly   421 NEFRPERF-SPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSA 479
            ..|:|||: ..:.::..|.:|::||..||:||||.:|..:|.:..::.:|:::...|..|
  Fly   425 LVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGA 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	116/479 (24%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	114/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910