Protein Alignment Cyp6a18 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 518
• Identity: 164/518 - (31%)
• Similarity: 262/518 - (50%)
• Gaps: 60/518 - (11%)

  Fly    12 VALLAIVTYILHRKLT----YFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAP 72
            :.||||:..:|:|..|    .||::|||..||.|..|.:..|  ...:.:...|.|.||..:...
Mouse    12 LVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNY--YTGIWKFDMECYEKYGKTWGL 74

  Fly    73 FVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK------GIYYNEKDDPMSAHLFNLDGPQWR 130
            |.|    |.|...:.|.|..|.:|:|: .|.||::      ||        ||..:......:|:
Mouse    75 FDG----QTPLLVITDPETIKNVLVKDCLSVFTNRREFGPVGI--------MSKAISISKDEEWK 127

  Fly   131 LLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIK 195
            ..|:.||.|||||::|.|:|.:....:..:..:.::..:...:.::|::..:::|||.:.:||:.
Mouse   128 RYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITSTSFGVN 192

  Fly   196 CNSLRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIVKE 256
            .:||.:.:..|:...::.| :|.....|.|.::  :|.|.   ..|.:|.......||:::.|..
Mouse   193 VDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVL--FPLLTPVYEMLNICMFPNDSIEFFKKFVDR 255

  Fly   257 TVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMG 320
            ....|...|.| |.||:.:::...|..    ::.:..|..:..||..|:.:|..||::|:|||:.
Mouse   256 MQESRLDSNQKHRVDFLQLMMNSHNNS----KDKDSHKAFSNMEITVQSIIFISAGYETTSSTLS 316

  Fly   321 FALYELAKNPSIQDKVRAELGQVLEQHDQKFTYEC--IKDLKYLDQVINETLRHYTIVPNVDRVA 383
            |.||.||.:|.||.|::||:.:.|   ..|.|..|  :.:::|||.|:|||||.|.||..::||.
Mouse   317 FTLYCLATHPDIQKKLQAEIDKAL---PNKATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVC 378

  Fly   384 AKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGP 448
            .|...:.|   ..|..|..|:|||.|:||||..:|:|.||:|||||.|.........:||||.||
Mouse   379 KKDVELNG---VYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGP 440

  Fly   449 RNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFD----------------PHSAILLG 495
            |||||:||..|..::.:..:::||:|.||..|..||...                |..|::.|
Mouse   441 RNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPRDAVITG 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	143/456 (31%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	142/449 (32%)