DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	509	Identity:	164/509 - (32%)
Similarity:	262/509 - (51%)	Gaps:	50/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VALLAIVTYILHRKLT----YFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAP 72
            :.||||:..:|:|..|    .||::|||..||.|..|.:..|  ...:.:...|.|.||..:...
Mouse    12 LVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNY--YTGIWKFDMECYEKYGKTWGL 74

  Fly    73 FVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK------GIYYNEKDDPMSAHLFNLDGPQWR 130
            |.|    |.|...:.|.|..|.:|:|: .|.||::      ||        ||..:......:|:
Mouse    75 FDG----QTPLLVITDPETIKNVLVKDCLSVFTNRREFGPVGI--------MSKAISISKDEEWK 127

  Fly   131 LLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIK 195
            ..|:.||.|||||::|.|:|.:....:..:..:.::..:...:.::|::..:::|||.:.:||:.
Mouse   128 RYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITSTSFGVN 192

  Fly   196 CNSLRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIVKE 256
            .:||.:.:..|:...::.| :|.....|.|.::  :|.|.   ..|.:|.......||:::.|..
Mouse   193 VDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVL--FPLLTPVYEMLNICMFPNDSIEFFKKFVDR 255

  Fly   257 TVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMG 320
            ....|...|.| |.||:.:::...|..    ::.:..|..:..||..|:.:|..||::|:|||:.
Mouse   256 MQESRLDSNQKHRVDFLQLMMNSHNNS----KDKDSHKAFSNMEITVQSIIFISAGYETTSSTLS 316

  Fly   321 FALYELAKNPSIQDKVRAELGQVLEQHDQKFTYEC--IKDLKYLDQVINETLRHYTIVPNVDRVA 383
            |.||.||.:|.||.|::||:.:.|   ..|.|..|  :.:::|||.|:|||||.|.||..::||.
Mouse   317 FTLYCLATHPDIQKKLQAEIDKAL---PNKATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVC 378

  Fly   384 AKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGP 448
            .|...:.|   ..|..|..|:|||.|:||||..:|:|.||:|||||.|.........:||||.||
Mouse   379 KKDVELNG---VYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGP 440

  Fly   449 RNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILLGI 496
            |||||:||..|..::.:..:::||:|.||..|..||      ...|...|:|.:
Mouse   441 RNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	152/479 (32%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	153/480 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720