DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	142/524 - (27%)
Similarity:	246/524 - (46%)	Gaps:	63/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGY--KKTRTVHEIHQEYYNKYRNS 69
            ||.:| |:||::...|....:|:|:||||..|..|..|:....  :|...|::| .|.|.:|:|:
  Fly     8 LFVIA-AILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDI-DEIYEQYKNT 70

  Fly    70 KAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGI--YYNEKDDPMSA-HLFNLDGPQWRL 131
            .: .||.:..:.|...|...|.|.:|.:.:|.:|.|..:  :.:.|.||:.| :.|.|.|..|:.
  Fly    71 DS-IVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKE 134

  Fly   132 LRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSI------LDVRDLVARFTVDVIGTC 190
            .|::::...::.::|..||..:.|.::|:    |.:...|:      |:.:||...:|.:||..|
  Fly   135 RRAEVTPGLSANRVKAAYPVSLRVCKKFV----EYIRRQSLMAPAQGLNAKDLCLCYTTEVISDC 195

  Fly   191 AFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVK 255
            ..||...|..|.....:...:|....|......:.:...:|.:.:...:......:..|:..:::
  Fly   196 VLGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLMQ 260

  Fly   256 ETVTLREKENI--KRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSST 318
            :.:.:|.:...  :|:||::.::.|:.:           |||...|:.:....|...||:|::..
  Fly   261 KCIQVRRESPAAQQRDDFLNYMLQLQEK-----------KGLNAAELTSHTMTFLTDGFETTAQV 314

  Fly   319 MGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVA 383
            :...|..||:||..|.|:|.|:|..      :.|:|.|.:|.:.:..|:||||.::.|     :|
  Fly   315 LTHTLLFLARNPKEQMKLREEIGTA------ELTFEQISELPFTEACIHETLRIFSPV-----LA 368

  Fly   384 AKRFVV-------PGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERF-SPEESAK--RPS 438
            |::.|.       .......:..|..||||.:|:||||..|.||..|:|||| :....||  |..
  Fly   369 ARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQ 433

  Fly   439 VAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP-----DPLTFDPHSAILLGIKG 498
            ..:..||:|||.|.|:||...|.:..|..:::||.......|.     |...|.|      .:||
  Fly   434 GLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMP------ALKG 492

  Fly   499 GIQL 502
            |:.|
  Fly   493 GVWL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	129/493 (26%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	123/469 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460946
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900