DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	576	Identity:	132/576 - (22%)
Similarity:	229/576 - (39%)	Gaps:	130/576 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLTYFLFQVAVALLAIVTYILHRKLT-YFK---------RRGIPYDKP---HPLRGNMEGY--- 49
            ::.|.|...|..|||.:|.:...|.|. .||         |:...:.:|   |.|.|:|..|
Mouse    14 LEKTAFRVYVVSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMYLPN 78

  Fly    50 --------KKTRTVHEI---------------HQEYYNKYRNSKAPFVG----FYLFQKPAAFVI 87
                    |...|:|.|               |.:|......:.|....    ||.|.||
Mouse    79 EKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKP----- 138

  Fly    88 DLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTV 152
              .|...:||..                          |.:|...|..|:..|....:|    ..
Mouse   139 --WLGDGLLISK--------------------------GNKWSRHRRLLTPAFHFDILK----PY 171

  Fly   153 VSVAEEFMAVMHEK----VSENSI--LDVRDLVARFTVDVIGTCAFGIKCNSLRDEKAEFLH--F 209
            :.:..:...:||.|    ::|.|:  .|:.:.::..|:|.:..|.|... :..::..::::.  .
Mouse   172 MKIFNQCTNIMHAKWRRHLAEGSVTSFDMFEHISLMTLDSLQKCVFSYN-SDCQERMSDYISSII 235

  Fly   210 GRRALLDSRHGNLVSGLMRSYPNLA--RRLGLCRNTAQIQEFYQRIVKE----------TVTLRE 262
            ...||:..|...|...|...|...|  ||.....:|  :..|...:::|          ...|:.
Mouse   236 ELSALVVRRQYRLHHYLDFMYYLTADGRRFRQACDT--VHNFTTEVIQERRQALRQQGAEAWLKA 298

  Fly   263 KENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELA 327
            |:. |..||:|:|:..|:::.         |.|:.::|.|:|..|...|.||:||.:.:||:.||
Mouse   299 KQG-KTLDFIDVLLLAKDEEG---------KELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLA 353

  Fly   328 KNPSIQDKVRAELGQVLEQHD-QKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPG 391
            |.|..|:|.|.|:.:|::..: ::..::.:..|.:....|.|:||.:..|..:.|...:...:|.
Mouse   354 KYPEYQEKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPD 418

  Fly   392 NPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRF 456
            ..  ||..|...::.....||:|.::|:...:.|.||.|:...:|..:|::||..|||||||..|
Mouse   419 GR--VIPKGIICLVSIYGTHHNPIVWPDSKVYNPYRFDPDTPQQRSPLAFVPFSAGPRNCIGQSF 481

  Fly   457 GQMQARIGLAMLIKNFTFS-----PCSATPDPLTFDPHSAILLGIKGGIQLKVEAI 507
            ...:.|:.:|:.:..|..|     .....|:         ::|..:.|:.|.||.:
Mouse   482 AMAEMRVVVALTLLRFRLSVDRTHKVRRKPE---------LILRTENGLWLNVEPL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	118/524 (23%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	115/515 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900