DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	134/591 - (22%)
Similarity:	231/591 - (39%)	Gaps:	160/591 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLTYFLFQVAVALLAIVTYILHRKLTY-FK---------RRGIPYDKP---HPLRGNMEGY--- 49
            ::.|.|...|..|||..:.::|.|.|.. ||         ||...:.:|   |.|.|:|..|
  Rat    14 LEKTAFRVYVLSALLLFLLFLLFRLLLQAFKLFSDFRITCRRLSCFPEPPGRHWLLGHMSMYLPN 78

  Fly    50 --------KKTRTVHEI---------------HQEYYNKYRNSKAPFVG----FYLFQKPAAFVI 87
                    |...|:|.|               |.:|......:.|....    ||.|.||
  Rat    79 EKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKP----- 138

  Fly    88 DLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTV 152
              .|...:||..                          |.:|...|..|:..|....:|    ..
  Rat   139 --WLGDGLLISK--------------------------GNKWSRHRRLLTPAFHFDILK----PY 171

  Fly   153 VSVAEEFMAVMHEK----VSENSI--LDVRDLVARFTVDVIGTCAFGIK--C--------NSLRD 201
            :.:..:.:.:||.|    ::|.|:  .|:.:.|:..|:|.:..|.|...  |        :|:.:
  Rat   172 MKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSLQKCVFSYSSDCQEKLSDYISSIIE 236

  Fly   202 EKA-------------EFLHF----GR--RALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQ 247
            ..|             :|:::    ||  |...|:.| |..:.:::......|.||
  Rat   237 LSALVVRRQYRLHHYLDFIYYLTADGRRFRQACDTVH-NFTTEVIQQRRRALRELG--------- 291

  Fly   248 EFYQRIVKETVTLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGF 312
                    ....|:.|:. |..||:|:|:..|:::.         |.|:.::|.|:|..|...|.
  Rat   292 --------AEAWLKAKQG-KTLDFIDVLLLAKDEEG---------KELSDEDIRAEADTFMFEGH 338

  Fly   313 DTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHD-QKFTYECIKDLKYLDQVINETLRHYTIV 376
            ||:||.:.:||:.|||.|..|||.|.|:.:|::..: ::..::.:..|.:....|.|:||.:..|
  Rat   339 DTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKESLRQFPPV 403

  Fly   377 PNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAW 441
            ..:.|...:...:|...  :|..|...::.....|::|.::|:...:.|.||.|:...:|..:|:
  Rat   404 TLISRRCTEDIKLPDGR--IIPKGIICLVSIYGTHYNPLVWPDSKVYNPYRFDPDIPQQRSPLAF 466

  Fly   442 LPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFS-----PCSATPDPLTFDPHSAILLGIKGGIQ 501
            :||..|||||||..|...:.|:.:|:.:..|..|     .....|:         ::|..:.|:.
  Rat   467 VPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVRRKPE---------LILRTENGLW 522

  Fly   502 LKVEAI 507
            |.||.:
  Rat   523 LNVEPL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	119/539 (22%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	112/516 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900