DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	130/536 - (24%)
Similarity:	236/536 - (44%)	Gaps:	69/536 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLFQVAVALLAIVTYILHRKLTYFK--RRGIPYDKPHPLRGNMEGYKKTRTVHE----IHQEYYN 64
            :|..:.|....::.|||.:....|:  ||...:.:| |.|..:.|:.......|    ..|....
  Rat    19 WLLLLLVGASCLLAYILPQVYAVFENSRRLRRFPQP-PTRNWLFGHLGLIQSSEEGLLYIQSLSR 82

  Fly    65 KYRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQW 129
            .:|:....:||.:   .|...:......|.:::...|......::|......:...|....|.:|
  Rat    83 TFRDVCCWWVGPW---HPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGLLLSTGDKW 144

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK----VSENSI-LDVRDLVARFTVDVIGT 189
            ...|..|:..|....:|    ..|.:..:...:||.|    .|:.|. ||:.:.::..|:|.:..
  Rat   145 SRHRHMLTPAFHFNILK----PYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQK 205

  Fly   190 CAFGIKCNSLRDEKAEFLH--FGRRALLDSRHGNLVSGLMRSYPNLARRL---GL-----CRNTA 244
            |.|....| .:::.:|::.  ....||:..||.:|:     .|.:|...|   |:     ||
  Rat   206 CVFSFDSN-CQEKPSEYITAILELSALVARRHQSLL-----LYVDLFYHLTRDGMRFRKACR--- 261

  Fly   245 QIQEFYQRIVKE---TV-------TLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDE 299
            .:.:|...:::|   |:       .|:.|...|..||:|:|:..|:      |:||   .|:.::
  Rat   262 LVHDFTDAVIRERRRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKD------EHGE---ALSDED 317

  Fly   300 IVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVL-EQHDQKFTYECIKDLKYLD 363
            |.|:|..|...|.||::|.:.:.||.|||:|..|::.|.|:.::| ::..::..::.:..|.:|.
  Rat   318 IRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLT 382

  Fly   364 QVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERF 428
            ..|.|:||.:.....:.|...:..::|...  ||..|....|.....||:|:::|:|..:.|.||
  Rat   383 MCIKESLRLHPPATAISRCCTQDIMLPDGR--VIPKGVICRISIFGTHHNPAVWPDPEVYNPFRF 445

  Fly   429 SPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP--DPLTFDPHSA 491
            ..:....|..:|::||..|||||||..|...:.::.||:.:..|...|....|  .|       .
  Rat   446 DADNGEGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKP-------E 503

  Fly   492 ILLGIKGGIQLKVEAI 507
            ::|..:||:.|:||.:
  Rat   504 LILRAEGGLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	120/497 (24%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	114/474 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900