DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	140/552 - (25%)
Similarity:	235/552 - (42%)	Gaps:	111/552 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAIVTYILHRKL--TY------FKRRGIPYDKPH--------PLRGNMEGYKKTRTVHEIHQEY 62
            ||...::||.|.|  ||      .:.|..|.....        .::.|.||   .|.|.|:.|.:
  Rat    23 LLGAASWILARILAWTYSFCENCSRLRCFPQSPKRNWFLGHLGTIQSNEEG---MRLVTEMGQTF 84

  Fly    63 YNKYRNSKAPFVGFYLFQKPAAFVIDLELAKQILI---KNFSNFTDKGIYYNEKDDPMSAHLFNL 124
            .:.:.....|.:.......| |||..|..|..::.   ..|..|....         :...||..
  Rat    85 RDIHLCWLGPVIPVLRLVDP-AFVAPLLQAPALVAPKDTTFLRFLKPW---------LGDGLFLS 139

  Fly   125 DGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK-----VSENSILDVRDLVARFTV 184
            .|.:|...|..|:..|....:|    ..|.:..:.:.:||.|     :..::.|::.:.::..|:
  Rat   140 SGDKWSRHRRLLTPAFHFDILK----PYVKIFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTL 200

  Fly   185 DVIGTCAFGIKCN----------------SLRDEKA-------EFLHF----GR--RALLDSRHG 220
            |.:..|.||...|                ||..:::       :||::    ||  |...|..|
  Rat   201 DSLQKCLFGFDSNCQESPSEYISAILELSSLIIKRSQQLFLYLDFLYYRTADGRRFRKACDLVH- 264

  Fly   221 NLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKETVTLREKENIKRNDFMDMLIGLKNQKNMT 285
            |....::|.    .|||...:.|   .||.:.        :.|...|..||:|:|:..|:
  Rat   265 NFTDAVIRE----RRRLLSSQGT---DEFLES--------KTKSKSKTLDFIDVLLLAKD----- 309

  Fly   286 LENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVL-EQHDQ 349
             |:|   |.|:.::|.|:|..|...|.||::|.:.:.||.||::|..|::.|.|:.::| ::..:
  Rat   310 -EHG---KELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPE 370

  Fly   350 KFTYECIKDLKYLDQVINETLRHYTIVPNVD--RVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHH 412
            :..::.:..|.:|...|.|:||.:.  |.:|  |...:..|:|...  ||..|...:|....|||
  Rat   371 EIEWDDLAQLPFLTMCIKESLRLHP--PAIDLLRRCTQDIVLPDGR--VIPKGNICVISIFGIHH 431

  Fly   413 DPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPC 477
            :||::|:|..|.|.||..|...||..::::||..|||||||..|...:.::.:|:.:..|...|.
  Rat   432 NPSVWPDPEVFDPFRFDSENRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRFRVLPD 496

  Fly   478 SATP--DPLTFDPHSAILLGIKGGIQLKVEAI 507
            ...|  .|       .|:|..:||:.|::|.:
  Rat   497 DKEPRRKP-------EIILRAEGGLWLRMEPL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	129/515 (25%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	129/516 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900