Protein Alignment Cyp6a18 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 142/554 - (25%)
• Similarity: 240/554 - (43%)
• Gaps: 115/554 - (20%)

  Fly    10 VAVALLAIVTYILHRKLTYFKR----RGIP-YDKPHPLRGNM-----EGYKKTRTVHEIHQ---E 61
            :::|..::|..:|.|..:|.::    |.|| ..:.:||.|:.     :|       .|..|   |
Human    22 LSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDG-------REFFQQIIE 79

  Fly    62 YYNKYRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDG 126
            |..:||:  .|.:..::...|...:.:.|..:.||..  |...||...|...:..:...|....|
Human    80 YTEEYRH--MPLLKLWVGPVPMVALYNAENVEVILTS--SKQIDKSSMYKFLEPWLGLGLLTSTG 140

  Fly   127 PQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDV----- 186
            .:||..|..|:.||.           .::.|:|:.:|:|:.   :|| |:.|......:.
Human   141 NKWRSRRKMLTPTFH-----------FTILEDFLDIMNEQA---NIL-VKKLEKHINQEAFNCFF 190

  Fly   187 -IGTCAFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGL----------- 239
             |..||..|.|     |.|...:.|.::..||.:   |..:.|....:.||:.:
Human   191 YITLCALDIIC-----ETAMGKNIGAQSNDDSEY---VRAVYRMSEMIFRRIKMPWLWLDLWYLM 247

  Fly   240 ------CRNTAQI-QEFYQRIVKETVT-LREKENI------------KRNDFMDMLIGLKNQKNM 284
                  .:.:.|| ..|...::.|... :...|:.            ||..|:|:|:.:.:.:..
Human   248 FKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGN 312

  Fly   285 TLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQ 349
            .|.:         ::|..:...|...|.||:::.:.::||.|..||.:|.||..||..|..:.|:
Human   313 RLSH---------EDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDR 368

  Fly   350 KFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDP 414
            ..|.|.:|.|:||:.||.||||.:..||...|..::...|.|..  |::..::|||| .|:|.||
Human   369 PATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYR--VLKGTEAVIIP-YALHRDP 430

  Fly   415 SIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSA 479
            ..:|.|.||:||||.||.:..|...|::||..|||||||.:|..|:.:..|:.::::|.......
Human   431 RYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQK 495

  Fly   480 TPDPLTFDPHSAILLGIKG--------GIQLKVE 505
            ..:           ||::|        ||.:|::
Human   496 REE-----------LGLEGQLILRPSNGIWIKLK 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	121/474 (26%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	127/488 (26%)