Protein Alignment Cyp6a18 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_001287562.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 136/547 - (24%)
• Similarity: 229/547 - (41%)
• Gaps: 96/547 - (17%)

  Fly     1 MQLTYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNK 65
            :|:|..|..:.:.:.|...| |||:......:..|....|.|.|:::.::..:.:..|.:..  |
Human    19 LQVTSLLILLLLLIKAAQLY-LHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERV--K 80

  Fly    66 YRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAH---------- 120
            ...|..|:  :....|....:.|.:..|.||               .:.||.| |
Human    81 TFPSACPY--WIWGGKVRVQLYDPDYMKVIL---------------GRSDPKS-HGSYKFLAPRI 127

  Fly   121 ---LFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVM---HEKVSENSILDVRDLV 179
               |..|:|..|...|..|:..|.:..:|   |.|..:|:....::   .|.:.::|.|:|...|
Human   128 GYGLLLLNGQTWFQHRRMLTPAFHNDILK---PYVGLMADSVRVMLDKWEELLGQDSPLEVFQHV 189

  Fly   180 ARFTVDVIGTCAFGIKCNSLRDEKAE-FLHFGRRALLDSRHGNLVSGLMRS-------------- 229
            :..|:|.|...||..:.:...|..:: ::    :|:.|.  .:||...||:
Human   190 SLMTLDTIMKSAFSHQGSIQVDRNSQSYI----QAISDL--NSLVFCCMRNAFHENDTIYSLTSA 248

  Fly   230 --YPNLARRLGLCRNTAQIQEFYQRIVKETVTLREKENIKRN---DFMDMLIGLKNQKNMTLENG 289
              :.:.|.:|........||....::.||    .|.|.|||.   ||:|:|:..|      :|||
Human   249 GRWTHRACQLAHQHTDQVIQLRKAQLQKE----GELEKIKRKRHLDFLDILLLAK------MENG 303

  Fly   290 EVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYE 354
            .:   |:..::.|:...|...|.||::|.:.:.||.||.:|..|::.|.|:..:|.. ....|:.
Human   304 SI---LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD-GASITWN 364

  Fly   355 CIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGN---PKFVIEAGQSVIIPSSAIHHDPSI 416
            .:..:.|....|.|.||.|..||.:.|..:.....|..   ||     |..|::....:||:|.:
Human   365 HLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPK-----GIMVLLSIYGLHHNPKV 424

  Fly   417 YPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP 481
            :|....|.|.||:|  .:.:.|.|:|||..|.|||||.:|...|.::..|:.:..|     ...|
Human   425 WPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRF-----ELLP 482

  Fly   482 DPLTFD-PHSAILLGIKGGIQLKVEAI 507
            ||.... |.:.::|..|.||.|::..:
Human   483 DPTRIPIPMARLVLKSKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	127/505 (25%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	127/507 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900