Protein Alignment Cyp6a18 and Cyp4a8

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_113793.2
• Gene: Cyp4a8 / 266674
• RGDID: 628846
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 562
• Identity: 134/562 - (23%)
• Similarity: 228/562 - (40%)
• Gaps: 117/562 - (20%)

  Fly     3 LTYFLF--------QVAVALLAIV------TYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTR 53
            |::.:|        |:|..|..::      .:.|||:......:..|....|...|
  Rat     6 LSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFG--------- 61

  Fly    54 TVHEI-----HQEYYNKYRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEK 113
              |:|     .|:...:.:|..:....:.........|.|.:..|.||               .:
  Rat    62 --HKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLIL---------------GR 109

  Fly   114 DDPMSAH------------LFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK 166
            .||.|.|            |..|:|..|...|..|:..|....:|    ..|.:..:.:.:|.:|
  Rat   110 SDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLK----PYVGIMADSVRIMLDK 170

  Fly   167 ----VSENSILDVRDLVARFTVDVIGTCAFGIKCNSLRDEKAEF----------LHFGRRALLDS 217
                |.::|.|::...:...|:|.|..|||..:.:...|.|.:.          |.|.|  :.:.
  Rat   171 WEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFR--IRNI 233

  Fly   218 RHGNLVSGLMRSYPNLARRLGLCRNTAQI-QEFYQRIVK-ETVTLREKENI------KRNDFMDM 274
            .|.|   .::.|..:..|:   .|:..|: .|...:::| ....|:::|.:      :|.||:|:
  Rat   234 FHQN---DIIYSLSSNGRK---ARSAWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDI 292

  Fly   275 LIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAE 339
            |:..:      :|||   ..|:..::.|:...|...|.||::|.:.:..|.||.||..|...|.|
  Rat   293 LLFAR------IENG---SSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKE 348

  Fly   340 LGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGN---PKFVIEAGQ 401
            : |.|.......|::.:..:.|....|.|.||.|..|..|.|:.:.....|..   ||     |.
  Rat   349 I-QSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPK-----GI 407

  Fly   402 SVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLA 466
            :|::....:||:|:::|.|..|.|.||:||.|  |.|.::|||..|.|||||.:|...:.::.:|
  Rat   408 TVMLSFYGLHHNPTVWPNPEVFDPYRFAPESS--RHSHSFLPFSGGARNCIGKQFAMNELKVAVA 470

  Fly   467 MLIKNFTFSPCSATPDPLTFD-PHSAILLGIKGGIQLKVEAI 507
            :.:..|     ...|||.... |...::|..|.||.|:::.:
  Rat   471 LTLLRF-----ELLPDPTRIPIPIPRLVLKSKNGIYLRLKKL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	116/467 (25%)
Cyp4a8	NP_113793.2	CYP4B-like	70..503	CDD:410771	120/481 (25%)