Protein Alignment Cyp6a18 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 142/533 - (26%)
• Similarity: 244/533 - (45%)
• Gaps: 75/533 - (14%)

  Fly     6 FLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRG--------NMEGYKKTRTVHEIHQEY 62
            |:|.:|:.||..:...|.|:......|..|....|...|        |||      .:.||.::|
Human    18 FVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNME------KLEEIIEKY 76

  Fly    63 YNKYRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDP--MSAHLFNLD 125
            ...:.....||..|:.       :.|.:.||.:|.:     ||....|.:|..|  :...|..||
Human    77 PRAFPFWIGPFQAFFC-------IYDPDYAKTLLSR-----TDPKSQYLQKFSPPLLGKGLAALD 129

  Fly   126 GPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKV--SENSILDVRDLVARFTVDVIG 188
            ||:|...|..|:..|....:| .|..|::.:.:.|....||:  ::::.::|.:.:...::|:|.
Human   130 GPKWFQHRRLLTPGFHFNILK-AYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIM 193

  Fly   189 TCAF----GIKCNSLRDEKAEFLHFGRRALLDSR------HGNLVSGLMRS---YPNLARRLGLC 240
            .|||    ..:.||..|..|:.: |....::..|      |.:::..|...   :..|:|.|...
Human   194 KCAFSKETNCQTNSTHDPYAKAI-FELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQY 257

  Fly   241 RNTAQIQE---FYQRIVKETVTLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVA 302
            .:|. |||   ..|..||:..|.:.    |..||:|:::..|:      |:|.....:   ::.:
Human   258 TDTI-IQERKKSLQAGVKQDNTPKR----KYQDFLDIVLSAKD------ESGSSFSDI---DVHS 308

  Fly   303 QAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVIN 367
            :...|.:||.||.::::.:.||.||.||..|::.|.|:..:|.. ....|::.:.::.|....|.
Human   309 EVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSITWDQLGEMSYTTMCIK 372

  Fly   368 ETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEE 432
            ||.|....||::.|..:|....|..  ..:.||.:|::....:||:|:::..|..|.|.|||.|.
Human   373 ETCRLIPAVPSISRDLSKPLTFPDG--CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435

  Fly   433 SAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPD---PLTFDPHSAILL 494
            |.:|...|:|||..|.|||||..|..::.::.:|:::.:|     ..|||   ||||..|  .:|
Human   436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF-----RVTPDPTRPLTFPNH--FIL 493

  Fly   495 GIKGGIQLKVEAI 507
            ..|.|:.|.::.:
Human   494 KPKNGMYLHLKKL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	123/452 (27%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	129/479 (27%)
		heme binding region	447..460		7/12 (58%)