DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	162/515 - (31%)
Similarity:	261/515 - (50%)	Gaps:	68/515 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAIVTYILH----RKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAPFV 74
            |||:|..:|:    |....||::|||..||.|..|.:..|.......::  |.:.||......|.
  Rat    14 LLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKFDV--ECHKKYGKIWGLFD 76

  Fly    75 GFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK------GIYYN----EKDDPMSAHLFNLDGPQ 128
            |    |.|...:.|.|:.|.:|:|. ||.||::      ||...    .||:            :
  Rat    77 G----QMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAISVSKDE------------E 125

  Fly   129 WRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFG 193
            |:..|:.||.|||||::|.|:|.:....:  :.|.:.:..:...:.|:::...:::|||.:.:||
  Rat   126 WKRYRALLSPTFTSGRLKEMFPVIEQYGD--ILVKYLRQEKGKPVPVKEVFGAYSMDVITSTSFG 188

  Fly   194 IKCNSLRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIV 254
            :..:||.:.|..|:...::.| :|......:|.::  :|.|.   ..|.:|.......||:::.|
  Rat   189 VNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVL--FPFLTPVYEMLNICMFPKDSIEFFKKFV 251

  Fly   255 ---KETVTLREKENIKRN--DFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDT 314
               |||    ..::::::  ||:.:::...|..    ::.|....|:..||.||:.:|..||::.
  Rat   252 YRMKET----RLDSVQKHRVDFLQLMMNAHNDS----KDKESHTALSDMEITAQSIIFIFAGYEP 308

  Fly   315 SSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNV 379
            :|||:.|.|:.||.:|..|.|::.|:.:.|...... ||:.:.:::|||.|:|||||.|.|...:
  Rat   309 TSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPP-TYDTVMEMEYLDMVLNETLRLYPIGNRL 372

  Fly   380 DRVAAKRFVVPG--NPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWL 442
            :||..|...:.|  .||     |..|:|||.|:|.||..:|||.||||||||.|.........:|
  Rat   373 ERVCKKDVEINGVFMPK-----GSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYL 432

  Fly   443 PFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILLGI 496
            |||.|||||||:||..|..::.|..:::||:|.||..|..||      ...|...|:|.:
  Rat   433 PFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTKPIILKV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	151/487 (31%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	152/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870