Protein Alignment Cyp6a18 and Cyp17a1

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_036885.2
• Gene: Cyp17a1 / 25146
• RGDID: 2456
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 522
• Identity: 124/522 - (23%)
• Similarity: 213/522 - (40%)
• Gaps: 71/522 - (13%)

  Fly     7 LFQVAVALLAIVTYILHRKLTYFKRRG--IPYDKPH-PLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            ::::...||.|:.|....|   .|..|  :|...|. ||.|::....:...:|....:...||
  Rat     1 MWELVGLLLLILAYFFWVK---SKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY-- 60

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEK--DDPMSAHLFNLDGPQWRL 131
              .|.....|.......:...:||:::|||....|:.:.....:.  .|......|...|..|.|
  Rat    61 --GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHL 123

  Fly   132 LRSKLSSTFTSGK-----MKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCA 191
            .|..:.|||:..|     .|.:.....|:.:  |.:.|:|.|    :|:...:.....::|....
  Rat   124 HRKLVFSTFSLFKDGQKLEKLICQEAKSLCD--MMLAHDKES----IDLSTPIFMSVTNIICAIC 182

  Fly   192 FGIKCNSLRDEKAEFLHFGRRALLDSR-HGNLVS--GLMRSYPNLARRLGLCRNTAQIQEFYQRI 253
            |.|.... :|.|...:......::|:. ..|||.  ..:..:||    .||     ::.:.|.::
  Rat   183 FNISYEK-KDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPN----KGL-----EVIKGYAKV 237

  Fly   254 VKETVT-----LREK-ENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMD-----EIVAQAFVF 307
            ..|.:|     .||| ::...:...|:||    |..|..:|....:|...|     .|:|.....
  Rat   238 RNEVLTGIFEKCREKFDSQSISSLTDILI----QAKMNSDNNNSCEGRDPDVFSDRHILATVGDI 298

  Fly   308 FIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRH 372
            |.||.:|:::.:.:.|..|..||.::.|::.|:.|.: ...:..|:.....|..|:..|.|.||.
  Rat   299 FGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYV-GFSRTPTFNDRSHLLMLEATIREVLRI 362

  Fly   373 YTIVP-------NVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSP 430
            ..:.|       |||. :...|.||.:        ..|::...|:|||.:.:.:|::|.||||..
  Rat   363 RPVAPMLIPHKANVDS-SIGEFTVPKD--------THVVVNLWALHHDENEWDQPDQFMPERFLD 418

  Fly   431 EESAK--RPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDP-LTFDPHSAI 492
            ...:.  .|:.::||||.|||:|||....:.:..:..|:|::.|..........| |..||....
  Rat   419 PTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVF 483

  Fly   493 LL 494
            |:
  Rat   484 LI 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	109/456 (24%)
Cyp17a1	NP_036885.2	CYP17A1	60..490	CDD:410766	110/460 (24%)