DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	152/532 - (28%)
Similarity:	261/532 - (49%)	Gaps:	58/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAPFV 74
            ::|.|||::.:......:..::.||.:.:|.|..||:..::  :...|.|.|...:|    .|..
  Rat    20 LSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR--QGFWESHLELRERY----GPLC 78

  Fly    75 GFYLFQKPAAFVIDLELAKQILIKNFSNFTDK---GIYYNEKDDP--MSAHLFNLDGPQWRLLRS 134
            |:||.::....:.|.::.|::|::|||||:::   |:      :|  ::..:..|...:|..:|.
  Rat    79 GYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGL------EPKLIADSVLMLRDRRWEEVRG 137

  Fly   135 KLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIKCNSL 199
            .|.|.|:..|:..|.|.:....|..::.:....:.....|::.....||.:|:.:.||||:.||.
  Rat   138 ALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQ 202

  Fly   200 RDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPN----LARRLGLCRNTAQIQEFYQRIVKETVTL 260
            ...:..|:...:|....|....|:: |:.|:|:    |||.|. .:|..::..|:..:::..:.|
  Rat   203 DAPEDPFVQHCQRVFAFSTPRPLLA-LILSFPSIMVPLARILP-NKNRDELNGFFNTLIRNVIAL 265

  Fly   261 REKENI--KRNDFMDMLIGLKNQKNMT-------------LENGE-------------VVKGLTM 297
            |:|:..  :|.||:.|:  |..|::|:             |.:.|             ..|.||:
  Rat   266 RDKQTAEERRGDFLQMV--LDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTV 328

  Fly   298 DEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYL 362
            |||..|||:|.|||.:.:::|:.|..|.||.:|..|:::..|:...:|:|.........:.|.||
  Rat   329 DEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYL 393

  Fly   363 DQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPER 427
            |.|:.||||.|.......|.||:...|.|..   |.||..:.|...|:||||..:|.|..|.|||
  Rat   394 DMVVAETLRMYPPAFRFTREAAQDCEVLGQH---IPAGSVLEIAVGALHHDPEHWPNPETFDPER 455

  Fly   428 FSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAI 492
            |:.|...::....:||||.|||:|:|:|.|.:..::.|..::..|.|..|..|..||..:..||
  Rat   456 FTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSA- 519

  Fly   493 LLGIKGGIQLKV 504
             |..|.|:.:|:
  Rat   520 -LCPKNGVYVKI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	145/502 (29%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	145/503 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770