Protein Alignment Cyp6a18 and CYP4Z1

DIOPT Version :9

• Sequence 1: NP_001287562.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 138/542 - (25%)
• Similarity: 227/542 - (41%)
• Gaps: 113/542 - (20%)

  Fly    14 LLAIVTYILHRKLTYFKRRG--------IPYDKPHPLRGNMEGY--KKTRTVHEIHQEYYNKYRN 68
            :|..::.:|.:.:..::||.        .|....|...|:.|.|  |:....|::.::|......
Human    18 ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPL 82

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSA--H----------L 121
            ...||..|:....|       :.|| ||:|              :.||.||  |          |
Human    83 WVGPFTMFFSVHDP-------DYAK-ILLK--------------RQDPKSAVSHKILESWVGRGL 125

  Fly   122 FNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMA-VMHEKVSENSILDVRDLVARFTVD 185
            ..|||.:|:..|..:...|....:| ::.|::|.:...|. ...|.:::||.|::...|:..|:|
Human   126 VTLDGSKWKKHRQIVKPGFNISILK-IFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLD 189

  Fly   186 VIGTCAF----GIKCNSLRDE--KA-------------EFLHFGRRALLDSRHGNLVSGLMRSYP 231
            .|..|||    .|:.:|..|.  ||             .|||........|..|.:.|
Human   190 SIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFS------- 247

  Fly   232 NLARRLGLCRNTAQIQEFYQRIVKETVTLREKENIK-----------RNDFMDMLIGLKNQKNMT 285
                     :...::.:|.::::::     .||::|           |.||:|:|:..|:
Human   248 ---------KFNQELHQFTEKVIQD-----RKESLKDKLKQDTTQKRRWDFLDILLSAKS----- 293

  Fly   286 LENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQK 350
                |..|..:..::.|:...|..||.||:||.:.:.||.|||.|..|.:.|.|:.::|.. ...
Human   294 ----ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSS 353

  Fly   351 FTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPS 415
            .|:|.:..:.|....|.|.||.|..|.|:.|:..|....|....  :.||.:|.|...|:||:|.
Human   354 ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRS--LPAGITVFINIWALHHNPY 416

  Fly   416 IYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSAT 480
            .:.:|..|.|.|||.|.|.|....|::||..|.|||||..|..::.::.:|:.:..|..:|..:.
Human   417 FWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481

  Fly   481 PDPLTFDPHSAILLGIKGGIQL 502
            |.    .|...::|..|.||.:
Human   482 PP----QPVRQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	133/510 (26%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	134/513 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810