Protein Alignment Cyp6a18 and Cyp3a9

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_671739.2
• Gene: Cyp3a9 / 171352
• RGDID: 708392
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 518
• Identity: 161/518 - (31%)
• Similarity: 257/518 - (49%)
• Gaps: 60/518 - (11%)

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            |:.|..:::.||.:  |..|.. ..||:.|||..||.|..|.:..|:|  ...|..:..:.||
  Rat    11 TWLLLVISLVLLYL--YGTHSH-GIFKKLGIPGPKPLPFLGTILAYRK--GFWEFDKYCHKKY-- 68

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTD-----------KGIYYNEKDDPMSAHL 121
              ....|.|..::|...:.|.::.|.:|:|. :|.||:           |.|..:|.:
  Rat    69 --GKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGILKKAISISEDE------- 124

  Fly   122 FNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDV 186
                  :|:.:|:.||.||||||:|.|:|.:....:..:..|.:...|.....::|:...:::||
  Rat   125 ------EWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDV 183

  Fly   187 IGTCAFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRS---YPNLA---RRLGLCRNTAQ 245
            |...:||:..:||.:.:..|:...::.|    ..::...|..|   :|.|.   ..|.:......
  Rat   184 ITATSFGVNVDSLNNPQDPFVEKIKKLL----KFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRD 244

  Fly   246 IQEFYQRIVKETVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFI 309
            :.:|::..|:.....|.||..| |.||:.::|   |.:|..:::..  |.|:..|||||:.:|..
  Rat   245 VIDFFKTSVERMKENRMKEKEKQRMDFLQLMI---NSQNSKVKDSH--KALSDVEIVAQSVIFIF 304

  Fly   310 AGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYT 374
            ||::|:||.:.|.||.||.:|.||.|::.|:...| .:....||:.:..::|||.|:|||||.|.
  Rat   305 AGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAAL-PNKAHATYDTLLQMEYLDMVVNETLRLYP 368

  Fly   375 IVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSV 439
            |...::||......:.|   ..|..|..|:||:.|:|.||..:|||.||||||||.:........
  Rat   369 IAGRLERVCKTDVEING---VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPY 430

  Fly   440 AWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILLGI 496
            .:||||.|||||||:||..|..::.|..:::||:|.||..|..||      ...|...:||.:
  Rat   431 MYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	141/452 (31%)
Cyp3a9	NP_671739.2	CYP3A	67..492	CDD:410743	142/454 (31%)