DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	545	Identity:	134/545 - (24%)
Similarity:	227/545 - (41%)	Gaps:	100/545 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAIVTYILHRKLTYF--------KRRGIPYDKPHP---------LRGNMEGYK-KTRTVHEIHQ 60
            ||...::||.|.|.:.        :.|..| ..|.|         ::.|.|..: .|...|:.|.
Mouse    23 LLGGASWILARILAWIYAFYDNCSRLRCFP-QPPKPSWFWGHLALMKNNEESMQFITHLGHDFHD 86

  Fly    61 EYYN-----------KYRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKNF-SNFTDKGIYYNEK 113
            .:.:           .:.|..||     |.|..||..     .|::.:..| ..:...|:.
Mouse    87 VHLSWVGPVYPILRLVHPNFIAP-----LLQASAAVA-----PKEMTLYGFLKPWLGDGLL---- 137

  Fly   114 DDPMSAHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK-----VSENSIL 173
               |||      |.:|...|..|:..|....:|    :.|.:..:.:.:||.|     ....|.|
Mouse   138 ---MSA------GDKWSHHRRLLTPAFHFDILK----SYVKIFNKSVNIMHAKWQCLASKGTSRL 189

  Fly   174 DVRDLVARFTVDVIGTCAFGIKCNSLRDEK---AEFLHFGRRALLDSRHGNLVSGLMRSYPNLAR 235
            |:.:.::..|:|.:..|.|.:..|....:.   |..|......:...|...|...|:.......|
Mouse   190 DMFEHISLMTLDSLQKCIFSVDSNCQESDSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGR 254

  Fly   236 RLGLCRNTAQ-IQEFYQRIVKETVT---------LREKENIKRNDFMDMLIGLKNQKNMTLENGE 290
            |.   |.... :..|...::||..:         |:.|...|..||:|:|:..::      |:|
Mouse   255 RF---RKACDLVHNFTDAVIKERRSTLNTQGVEFLKAKAKTKTLDFIDVLLMAED------EHG- 309

  Fly   291 VVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHD-QKFTYE 354
              |||:.::|.|:|..|...|.||::|.:.:.||.||::|..|::.|.|:.::|...| ::..::
Mouse   310 --KGLSNEDIRAEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWD 372

  Fly   355 CIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPE 419
            .:..|.:|...|.|:||.:..|..:.|...:..::|...  .|..|...:|....:||:||::|:
Mouse   373 DLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGR--AIPKGNICVISIFGVHHNPSVWPD 435

  Fly   420 PNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP--D 482
            |..:.|.||.||...||..:|::||..|.|||||..|...:.::.||:.:..|...|....|  .
Mouse   436 PEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRILPDDKEPRRK 500

  Fly   483 PLTFDPHSAILLGIKGGIQLKVEAI 507
            |       .::|..:||:.|:||.:
Mouse   501 P-------ELILRAEGGLWLRVEPL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	124/508 (24%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	124/509 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900