DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	161/521 - (30%)
Similarity:	257/521 - (49%)	Gaps:	70/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVH---EIHQEYYNK 65
            |:.|....:.||.:.....|..   ||:.||...||.|..||:..|:     |   |..:..:.|
  Rat    11 TWMLLATILVLLYLYGTSTHGN---FKKLGISGPKPLPFVGNILAYR-----HGFWEFDRHCHKK 67

  Fly    66 YRNSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTD-----------KGIYYNEKDDPMS 118
            |    ....|||..::|...:.|.::.|.:|:|. :|.||:           |.|..:|.:
  Rat    68 Y----GDIWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSFGPAGILKKAITLSEDE---- 124

  Fly   119 AHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMA-VMHEKVSENSILDVRDLVARF 182
                     :|:.||:.||.||||||:|.|:|.:...|:..:. |.||....|.| .::|:...:
  Rat   125 ---------EWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPI-TMKDIFGAY 179

  Fly   183 TVDVIGTCAFGIKCNSLRDEKAEFLHFGRRAL----LDSRHGNLVSGLMRSYPNLA---RRLGLC 240
            ::|||...:||:..:||.:.:..|:...::.|    ||....:::     .:|.|.   ....:.
  Rat   180 SMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDPFFLSVI-----LFPFLTPVFEAFDIT 239

  Fly   241 RNTAQIQEFYQRIVKETVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQA 304
            .....:.:|::..|:.....|.:|.:| |.||:.::|..::..:.     |..:|||..|||||:
  Rat   240 VFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMINSQSSGDK-----ESHQGLTDVEIVAQS 299

  Fly   305 FVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINET 369
            ..|..||::|:||.:.||||.||.:|.:|.|::.|:...| .:....||:.:.:::|||.|:|||
  Rat   300 IFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL-PNKAPVTYDVLVEMEYLDMVLNET 363

  Fly   370 LRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESA 434
            ||.:.:...::||..|...:.|   ..|..|..|::|:.|:|.||..:|||.||.||||..:...
  Rat   364 LRLFPVGGRLERVCKKDVEING---VFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQD 425

  Fly   435 KRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLT------FDPHSAIL 493
            ......:||||.|||||||:||..|..:|.|..:::||:|..|..|..||.      |.|...|:
  Rat   426 SINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPII 490

  Fly   494 L 494
            |
  Rat   491 L 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	152/487 (31%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	151/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770