Protein Alignment Cyp6a18 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 112/457 - (24%)
• Similarity: 186/457 - (40%)
• Gaps: 63/457 - (13%)

  Fly    35 PY-DKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAPFVGFYLFQKPAAFVIDLELAKQIL-I 97
            || ..|.|..|:...:.|:..  |..:..|.||    .|...|.:..|...:::..:.|..:. .
Human    68 PYIFSPIPFLGHAIAFGKSPI--EFLENAYEKY----GPVFSFTMVGKTFTYLLGSDAAALLFNS 126

  Fly    98 KN--------FSNFT----DKGIYYNEKDDPMSAHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYP 150
            ||        :|..|    .||:.|   |.|....|     .|.::|:|.|:...        :.
Human   127 KNEDLNAEDVYSRLTTPVFGKGVAY---DVPNPVFL-----EQKKMLKSGLNIAH--------FK 175

  Fly   151 TVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIKCNSLRDEKAEFLHFGRRALL 215
            ..||:.|:......|...|:...:|.:.::...:.....|..|.:..|..:||...|:    |.|
Human   176 QHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLY----ADL 236

  Fly   216 D---SRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKETVTLREKENIKRNDFMDMLIG 277
            |   |....|:.|.: ..|:..||....|....|  ||:.|.|     |.:...|.:|.:..|:
Human   237 DGGFSHAAWLLPGWL-PLPSFRRRDRAHREIKDI--FYKAIQK-----RRQSQEKIDDILQTLL- 292

  Fly   278 LKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQ 342
                 :.|.::|   :.||.||:........:||..|||:|..:..:.||::.::|.|...|...
Human   293 -----DATYKDG---RPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT 349

  Fly   343 VLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPS 407
            |..::....||:.:|||..||:.|.||||....:..:.|:|.....|.|   :.|..|..|.:..
Human   350 VCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAG---YTIPPGHQVCVSP 411

  Fly   408 SAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNF 472
            :........:.|..:|.|:|:..:..|.....|::|||.|...|||..|..:|.:...:.:::.:
Human   412 TVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 476

  Fly   473 TF 474
            .|
Human   477 EF 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	102/421 (24%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	105/429 (24%)