DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	524	Identity:	164/524 - (31%)
Similarity:	267/524 - (50%)	Gaps:	61/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            |:.|..|::.||.:.....|   ..|||.|||...|.||.||:..|:  :.:.:...|.|.||
Human    11 TWLLLAVSLVLLYLYGTRTH---GLFKRLGIPGPTPLPLLGNVLSYR--QGLWKFDTECYKKY-- 68

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK------GIYYNEKDDPMSAHLFNLDG 126
              ....|.|..|.|...:.|.::.:.:|:|. :|.||::      |.        |.:.:...:.
Human    69 --GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF--------MKSAISLAED 123

  Fly   127 PQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCA 191
            .:|:.:||.||.||||||:|.|:|.:....:..:..:..:..:...:.::|:...:::|||...:
Human   124 EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188

  Fly   192 FGIKCNSLR-------DEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNL-----ARRLGLC-RNT 243
            ||:..:||.       :...:||.||   .||....:::     .:|.|     |..:.|. ::|
Human   189 FGVNIDSLNNPQDPFVESTKKFLKFG---FLDPLFLSII-----LFPFLTPVFEALNVSLFPKDT 245

  Fly   244 AQ-IQEFYQRIVKETVTLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVF 307
            .. :.:...|:.|..:..::|.   |.||:.::|..:|.|..     |..|.|:..|:.||:.:|
Human   246 INFLSKSVNRMKKSRLNDKQKH---RLDFLQLMIDSQNSKET-----ESHKALSDLELAAQSIIF 302

  Fly   308 FIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRH 372
            ..||::|:||.:.|.|||||.:|.:|.|::.|:..||...... ||:.:..::|||.|:|||||.
Human   303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRL 366

  Fly   373 YTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRP 437
            :.:...::|...|...:.|   ..|..|..|:||:.|:||||..:.||.||||||||.::.:..|
Human   367 FPVAIRLERTCKKDVEING---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP 428

  Fly   438 SVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIKGGIQL 502
            .: :.|||.|||||||:||..|..::.|..:::||:|.||..|..||..|...  ||..:..|.|
Human   429 YI-YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG--LLQPEKPIVL 490

  Fly   503 KVEA 506
            ||::
Human   491 KVDS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	150/486 (31%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	151/489 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720