Protein Alignment Cyp6a18 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_001287562.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 164/520 - (31%)
• Similarity: 265/520 - (50%)
• Gaps: 52/520 - (10%)

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVH--EIHQEYYNKY 66
            |:.|  :||:|:.:..|..|.. ..||:.|||...|.|..||:..|.|...:.  |.|::|...:
Human    11 TWLL--LAVSLVLLYLYGTHSH-GLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVW 72

  Fly    67 RNSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDP---MSAHLFNLDGP 127
                    |||..|:|...:.|.::.|.:|:|. :|.||::..:     .|   |.:.:...:..
Human    73 --------GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDE 124

  Fly   128 QWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAF 192
            :|:.|||.||.||||||:|.|.|.:....:..:..:..:......:.::|:...:::|||.:.:|
Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189

  Fly   193 GIKCNSLRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNL---ARRLGLCRNTAQIQEFYQRI 253
            |:..:||.:.:..|:...::.| .|......:|  :..:|.|   ...|.:|....::..|.::.
Human   190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLS--ITVFPFLIPILEVLNICVFPREVTNFLRKS 252

  Fly   254 VKETVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSS 317
            ||.....|.::..| |.||:.::|..:|.|..     |..|.|:..|:|||:.:|..||::|:||
Human   253 VKRMKESRLEDTQKHRVDFLQLMIDSQNSKET-----ESHKALSDLELVAQSIIFIFAGYETTSS 312

  Fly   318 TMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRV 382
            .:.|.:||||.:|.:|.|::.|:..||...... ||:.:..::|||.|:|||||.:.|...::||
Human   313 VLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERV 376

  Fly   383 AAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEG 447
            ..|...:.|   ..|..|..|:|||.|:|.||..:.||.:|.|||||.:.........:.|||.|
Human   377 CKKDVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438

  Fly   448 PRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIKGGIQ------LKVEA 506
            ||||||:||..|..::.|..:::||:|.||..|..||.        |.:.|.:|      ||||:
Human   439 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK--------LSLGGLLQPEKPVVLKVES 495

  Fly   507  506
            Human   496  495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	149/482 (31%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	150/485 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820